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Literature summary for 1.8.1.9 extracted from
- Control of thioredoxin reductase (trxB) transcription by SarA in Staphylococcus aureus (2010), J. Bacteriol., 192, 336-345.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thioredoxin disulfide + NADPH + H+ | Staphylococcus aureus | - |
thioredoxin + NADP+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Staphylococcus aureus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thioredoxin disulfide + NADPH + H+ | - |
Staphylococcus aureus | thioredoxin + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| thioredoxin reductase | - |
Staphylococcus aureus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Staphylococcus aureus | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Staphylococcus aureus | transcription of thioredoxin reductase is markedly elevated in the sarA mutant under conditions of aerobic, as well as micro-aerophilic growth, indicating that SarA acts as a negative regulator of thioredoxin reductase expression, 2-3fold higher level of thioredoxin reductase is observed in the sarA mutant as compared to the wild type strain | up |
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