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Literature summary for 1.8.1.9 extracted from

  • Myers, J.M.; Myers, C.R.
    The effects of hexavalent chromium on thioredoxin reductase and peroxiredoxins in human bronchial epithelial cells (2009), Free Radic. Biol. Med., 47, 1477-1485.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Cr6+ hexavalent chromium causes pronounced inhibition of TrxR, the inhibition of TrxR is not reversed by removal of residual Cr6+ or by NADPH. In cells treated with 0.025 or 0.050 mM Cr6+ for 90 min, TrxR activity is inhibited by 71 and 77%, respectively, while after 180 min of the same treatments, TrxR is inhibited by 97 and 85%, respectively Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BEAS-2B cell
-
Homo sapiens
-
bronchial epithelial cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
-
Homo sapiens 2-nitro-5-thiobenzoate + NADP+
-
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Synonyms

Synonyms Comment Organism
thioredoxin reductase
-
Homo sapiens
TrxR
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens
NADPH
-
Homo sapiens