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Literature summary for 1.8.3.2 extracted from
- Neuroblastoma-derived sulfhydryl oxidase, a new member of the sulfhydryl oxidase/Quiescin6 family, regulates sensitization to interferon gamma-induced cell death in human neuroblastoma cells (2003), Cancer Res., 63, 7742-7752.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene SOXN, DNA and amino acid sequence determination, gene maps to chromosome 9q34.3, subcloning in Escherichia coli strain DH10B, in vitro-transcription and -translation | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | antisense constructs of the SOXN gene in Tet21N neuroblastoma cells confer resistance to IFN-gamma-induced apoptosis, while ectopic overexpression in sense direction sensitizes the cells to induced cell death | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | - |
Homo sapiens | - |
- |
| nuclear membrane | asociated | Homo sapiens | 31965 | - |
| plasma membrane | outer, associated | Homo sapiens | 5886 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
x * 78000, glycosylated enzyme, x * 60000, non-glycosylated enzyme | Homo sapiens |
| 78000 | - |
x * 78000, glycosylated enzyme, x * 60000, non-glycosylated enzyme | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | enzyme is involved in regulation/deregulation of MYCN gene expression which is a critical determinant in neuroblastoma progression, enzyme renders the cell sensitive to IFN-gamma-induced apoptosis | ? | - |
? |  |
| R-SH + O2 | Homo sapiens | - |
R-S-S-R + H2O2 | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q6ZRP7 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | probably | Homo sapiens |
| additional information | enzyme contains a signal sequence | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | tissue distribution of enzyme expression | Homo sapiens | - |
| neuroblastoma cell line | several cell lines | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme is involved in regulation/deregulation of MYCN gene expression which is a critical determinant in neuroblastoma progression, enzyme renders the cell sensitive to IFN-gamma-induced apoptosis | Homo sapiens | ? | - |
? | |
| R-SH + O2 | - |
Homo sapiens | R-S-S-R + H2O2 | - |
ir | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 78000, glycosylated enzyme, x * 60000, non-glycosylated enzyme | Homo sapiens |
| More | enzyme contains a protein-disulfide-isomerase-type thioredoxin domain and a yeast ERV1 domain | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | enzyme belongs to the sulfhydryl oxidase/Quiescin6 family | Homo sapiens |
| neuroblastoma-derived sulfhydryl oxidase | - |
Homo sapiens |
| SOXN | - |
Homo sapiens |
| sulfhydryl oxidase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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