Cloned (Comment) | Organism |
---|---|
gene msrB, overexpression of wild-type enzyme and mutant enzymes in Escherichia coli strain DH5alpha | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine (R)-sulfoxide + thioredoxin | Escherichia coli | enzyme is involved in repairing of oxidized methionine residues in proteins | L-methionine + thioredoxin disulfide + H2O | - |
? | |
additional information | Escherichia coli | enzyme contributes to resistance against cadmium, physiological role | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
gene msrB, enzyme SelR which is a selenoprotein, enzyme is organized in a fusion protein together with MsrA, EC 1.8.4.B2 | - |
Purification (Comment) | Organism |
---|---|
recombinant enzyme from Escherichia coli strain DH5alpha | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine (R)-sulfoxide + thioredoxin | enzyme is involved in repairing of oxidized methionine residues in proteins | Escherichia coli | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form of the substrate | Escherichia coli | L-methionine + thioredoxin disulfide + H2O | - |
? | |
additional information | enzyme contributes to resistance against cadmium, physiological role | Escherichia coli | ? | - |
? | |
oxidized calmodulin + thioredoxin | enzyme reduces L-methionine (R)-sulfoxide of the protein substrate | Escherichia coli | partially reduced calmodulin + thioredoxin disulfide | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | MsrB has a highly conserved sequence among organisms | Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
methionine sulfoxide reductase | - |
Escherichia coli |
MsrB | - |
Escherichia coli |
SelR | - |
Escherichia coli |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Escherichia coli |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
L-methionine (R)-sulfoxide | in vitro, substrate free L-methionine (R)-sulfoxide | Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thioredoxin | - |
Escherichia coli |