Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | expression of MsrB is induced by dehydration and H2O2 | Arabidopsis thaliana | |
additional information | MsrB expression is induced by heat shock and alkylating methyl-methanesulfonate treatment | Saccharomyces cerevisiae |
Protein Variants | Comment | Organism |
---|---|---|
additional information | H2O2 shortens the life span of cells in constructed null mutants | Staphylococcus aureus |
additional information | H2O2 shortens the life span of cells in constructed null mutants | Escherichia coli |
additional information | H2O2 shortens the life span of cells in constructed null mutants, the mutants show decreased MsrB activity with age compared to the wild-type enzyme | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | selenium-adequate diet retains MsrB mRNA and protein expression at basal levels | Mus musculus | |
additional information | selenium-adequate diet retains MsrB mRNA and protein expression at basal levels | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine (R)-sulfoxide + thioredoxin | Staphylococcus aureus | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (R)-sulfoxide + thioredoxin | Mus musculus | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (R)-sulfoxide + thioredoxin | Escherichia coli | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (R)-sulfoxide + thioredoxin | Homo sapiens | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (R)-sulfoxide + thioredoxin | Sus scrofa | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (R)-sulfoxide + thioredoxin | Saccharomyces cerevisiae | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (R)-sulfoxide + thioredoxin | Arabidopsis thaliana | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
additional information | Arabidopsis thaliana | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins | ? | - |
? | |
additional information | Homo sapiens | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | ? | - |
? | |
additional information | Sus scrofa | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | ? | - |
? | |
additional information | Mus musculus | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview, oxidation of 2 essential methionine residues of HIV-2 particles can inactivate the virus and prevent infection of human cells | ? | - |
? | |
additional information | Staphylococcus aureus | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | ? | - |
? | |
additional information | Escherichia coli | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | ? | - |
? | |
additional information | Saccharomyces cerevisiae | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
- |
- |
Escherichia coli | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Staphylococcus aureus | - |
- |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Homo sapiens | - |
kidney | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Staphylococcus aureus | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Mus musculus | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Escherichia coli | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Homo sapiens | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Sus scrofa | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Saccharomyces cerevisiae | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Arabidopsis thaliana | L-methionine + thioredoxin disulfide + H2O | - |
? | |
additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins | Arabidopsis thaliana | ? | - |
? | |
additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | Homo sapiens | ? | - |
? | |
additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | Sus scrofa | ? | - |
? | |
additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview, oxidation of 2 essential methionine residues of HIV-2 particles can inactivate the virus and prevent infection of human cells | Mus musculus | ? | - |
? | |
additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | Staphylococcus aureus | ? | - |
? | |
additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | Escherichia coli | ? | - |
? | |
additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | Saccharomyces cerevisiae | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
methionine sulfoxide reductase | - |
Staphylococcus aureus |
methionine sulfoxide reductase | - |
Mus musculus |
methionine sulfoxide reductase | - |
Escherichia coli |
methionine sulfoxide reductase | - |
Homo sapiens |
methionine sulfoxide reductase | - |
Sus scrofa |
methionine sulfoxide reductase | - |
Saccharomyces cerevisiae |
methionine sulfoxide reductase | - |
Arabidopsis thaliana |
MsrB | - |
Staphylococcus aureus |
MsrB | - |
Mus musculus |
MsrB | - |
Escherichia coli |
MsrB | - |
Homo sapiens |
MsrB | - |
Sus scrofa |
MsrB | - |
Saccharomyces cerevisiae |
MsrB | - |
Arabidopsis thaliana |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thioredoxin | - |
Staphylococcus aureus | |
thioredoxin | - |
Mus musculus | |
thioredoxin | - |
Escherichia coli | |
thioredoxin | - |
Homo sapiens | |
thioredoxin | - |
Sus scrofa | |
thioredoxin | - |
Saccharomyces cerevisiae | |
thioredoxin | - |
Arabidopsis thaliana |