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Literature summary for 1.8.4.12 extracted from

  • Moskovitz, J.
    Methionine sulfoxide reductases: ubiquitous enzymes involved in antioxidant defense, protein regulation, and prevention of aging-associated diseases (2005), Biochim. Biophys. Acta, 1703, 213-219.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information expression of MsrB is induced by dehydration and H2O2 Arabidopsis thaliana
additional information MsrB expression is induced by heat shock and alkylating methyl-methanesulfonate treatment Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
additional information H2O2 shortens the life span of cells in constructed null mutants Staphylococcus aureus
additional information H2O2 shortens the life span of cells in constructed null mutants Escherichia coli
additional information H2O2 shortens the life span of cells in constructed null mutants, the mutants show decreased MsrB activity with age compared to the wild-type enzyme Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
additional information selenium-adequate diet retains MsrB mRNA and protein expression at basal levels Mus musculus
additional information selenium-adequate diet retains MsrB mRNA and protein expression at basal levels Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-methionine (R)-sulfoxide + thioredoxin Staphylococcus aureus MsrB is specific for the R-form L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (R)-sulfoxide + thioredoxin Mus musculus MsrB is specific for the R-form L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (R)-sulfoxide + thioredoxin Escherichia coli MsrB is specific for the R-form L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (R)-sulfoxide + thioredoxin Homo sapiens MsrB is specific for the R-form L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (R)-sulfoxide + thioredoxin Sus scrofa MsrB is specific for the R-form L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (R)-sulfoxide + thioredoxin Saccharomyces cerevisiae MsrB is specific for the R-form L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (R)-sulfoxide + thioredoxin Arabidopsis thaliana MsrB is specific for the R-form L-methionine + thioredoxin disulfide + H2O
-
?
additional information Arabidopsis thaliana recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins ?
-
?
additional information Homo sapiens recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview ?
-
?
additional information Sus scrofa recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview ?
-
?
additional information Mus musculus recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview, oxidation of 2 essential methionine residues of HIV-2 particles can inactivate the virus and prevent infection of human cells ?
-
?
additional information Staphylococcus aureus recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview ?
-
?
additional information Escherichia coli recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview ?
-
?
additional information Saccharomyces cerevisiae recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-
Escherichia coli
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Saccharomyces cerevisiae
-
-
-
Staphylococcus aureus
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
kidney
-
Mus musculus
-
liver
-
Mus musculus
-
lung
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-methionine (R)-sulfoxide + thioredoxin MsrB is specific for the R-form Staphylococcus aureus L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (R)-sulfoxide + thioredoxin MsrB is specific for the R-form Mus musculus L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (R)-sulfoxide + thioredoxin MsrB is specific for the R-form Escherichia coli L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (R)-sulfoxide + thioredoxin MsrB is specific for the R-form Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (R)-sulfoxide + thioredoxin MsrB is specific for the R-form Sus scrofa L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (R)-sulfoxide + thioredoxin MsrB is specific for the R-form Saccharomyces cerevisiae L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine (R)-sulfoxide + thioredoxin MsrB is specific for the R-form Arabidopsis thaliana L-methionine + thioredoxin disulfide + H2O
-
?
additional information recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins Arabidopsis thaliana ?
-
?
additional information recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview Homo sapiens ?
-
?
additional information recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview Sus scrofa ?
-
?
additional information recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview, oxidation of 2 essential methionine residues of HIV-2 particles can inactivate the virus and prevent infection of human cells Mus musculus ?
-
?
additional information recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview Staphylococcus aureus ?
-
?
additional information recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview Escherichia coli ?
-
?
additional information recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview Saccharomyces cerevisiae ?
-
?

Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase
-
Staphylococcus aureus
methionine sulfoxide reductase
-
Mus musculus
methionine sulfoxide reductase
-
Escherichia coli
methionine sulfoxide reductase
-
Homo sapiens
methionine sulfoxide reductase
-
Sus scrofa
methionine sulfoxide reductase
-
Saccharomyces cerevisiae
methionine sulfoxide reductase
-
Arabidopsis thaliana
MsrB
-
Staphylococcus aureus
MsrB
-
Mus musculus
MsrB
-
Escherichia coli
MsrB
-
Homo sapiens
MsrB
-
Sus scrofa
MsrB
-
Saccharomyces cerevisiae
MsrB
-
Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
Staphylococcus aureus
thioredoxin
-
Mus musculus
thioredoxin
-
Escherichia coli
thioredoxin
-
Homo sapiens
thioredoxin
-
Sus scrofa
thioredoxin
-
Saccharomyces cerevisiae
thioredoxin
-
Arabidopsis thaliana