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Literature summary for 1.8.4.12 extracted from

  • Picot, C.R.; Perichon, M.; Cintrat, J.C.; Friguet, B.; Petropoulos, I.
    The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts (2004), FEBS Lett., 558, 74-78.
    View publication on PubMed
Search for more literature for 1.8.4.12

Activating Compound

Activating Compound Comment Organism Structure
additional information oxidative stress, e.g. caused by H2O2 up to 0.4 mM, induces enzyme expresssion Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens downregulation of CBS-1 during replicative senescence of cells leads to accumulation of oxidized proteins and age-related increased oxidative damage ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 MsrB, one isozyme of which is termed CBS-1
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast WI-38 Homo sapiens
-
additional information enzyme expression level and methionine sulfoxide content in fibroblasts during development, overview Homo sapiens
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WI-38 cell embryonic fibroblast, activity during development: downregulation during replicative senescence Homo sapiens
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information downregulation of CBS-1 during replicative senescence of cells leads to accumulation of oxidized proteins and age-related increased oxidative damage Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CBS-1
-
 Homo sapiens
MsrB
-
 Homo sapiens
peptide methionine sulfoxide reductase
-
 Homo sapiens