Cloned (Comment) | Organism |
---|---|
expression of MsrB in Escherichia coli strain BL21(DE3) | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
calmodulin-L-methionine (R)-sulfoxide + thioredoxin | Homo sapiens | MsrB is specific for the R-form, enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues, which restores the calmodulin binding to adenylate cyclase of the pathogen Bordetella pertussis, which is an essential step for the bacterium to enter host cells, overview | calmodulin-L-methionine + thioredoxin disulfide + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant MsrB from Escherichia coli strain BL21(DE3) | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
calmodulin-L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form, enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues, which restores the calmodulin binding to adenylate cyclase of the pathogen Bordetella pertussis, which is an essential step for the bacterium to enter host cells, overview | Homo sapiens | calmodulin-L-methionine + thioredoxin disulfide + H2O | - |
? | |
calmodulin-L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form, recombinant human calmodulin, recombinant human enzyme, artificial system, determination of oxidized methionine residues being reduced by the enzyme, overview | Homo sapiens | calmodulin-L-methionine + thioredoxin disulfide + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MsrB | - |
Homo sapiens |
peptide methionine sulfoxide reductase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thioredoxin | - |
Homo sapiens |