Literature summary for 1.8.4.12 extracted from

Marchetti Maria, A.; Pizarro Gresin, O.; Sagher, D.; Deamicis, C.; Brot, N.; Hejtmancik, J.F.; Weissbach, H.; Kantorow, M.
Methionine sulfoxide reductases B1, B2, and B3 are present in the human lens and confer oxidative stress resistance to lens cells (2005), Invest. Ophthalmol. Vis. Sci., 46, 2107-2112.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	isozyme MsrB1 or selenoprotein R	Homo sapiens	5829	-
endoplasmic reticulum	isozyme MsrB3	Homo sapiens	5783	-
mitochondrion	isozyme MsrB2 or CBS-1, and isozyme MsrB3	Homo sapiens	5739	-
nucleus	isozyme MsrB1 or selenoprotein R	Homo sapiens	5634	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-methionine-(R)-S-oxide + thioredoxin	Homo sapiens	stereospecific reduction, the isozymes of MsrB are involved in lens cell viability and oxidative stress protection	L-methionine + thioredoxin disulfide + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isozymes MsrB1 or selenoprotein R, MsrB2 or CBS-1, and MsrB3	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bone marrow	isozyme MsrB1	Homo sapiens	-
cerebellum	isozyme MsrB2	Homo sapiens	-
colon	isozymes MsrB3 and MsrB2	Homo sapiens	-
heart	isozymes MsrB3 and MsrB2	Homo sapiens	-
kidney	isozyme MsrB1 and MsrB2	Homo sapiens	-
lens	epithelia and fibers, isozymes MsrB1 or selenoprotein R, MsrB2 or CBS-1, and MsrB3, differential expression patterns of isozymes, overview	Homo sapiens	-
additional information	tissue-specific expression of MsrB isozymes, overview	Homo sapiens	-
skeletal muscle	isozymes MsrB1 and MsrB2	Homo sapiens	-
small intestine	isozyme MsrB3	Homo sapiens	-
spleen	isozyme MsrB1	Homo sapiens	-
SRA01/04 cell	i.e. HLE cell, transformed human lens epithelial cells	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-methionine-(R)-S-oxide + thioredoxin	stereospecific reduction	Homo sapiens	L-methionine + thioredoxin disulfide + H2O	-	?
L-methionine-(R)-S-oxide + thioredoxin	stereospecific reduction, the isozymes of MsrB are involved in lens cell viability and oxidative stress protection	Homo sapiens	L-methionine + thioredoxin disulfide + H2O	-	?

Synonyms

Synonyms	Comment	Organism
CBS-1	-	Homo sapiens
methionine sulfoxide reductase B	-	Homo sapiens
MsrB	-	Homo sapiens
selenoprotein R	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
thioredoxin	-	Homo sapiens

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Release 2023.1 (January 2023)