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Literature summary for 1.8.4.12 extracted from

  • Dhandayuthapani, S.; Jagannath, C.; Nino, C.; Saikolappan, S.; Sasindran, S.J.
    Methionine sulfoxide reductase B (MsrB) of Mycobacterium smegmatis plays a limited role in resisting oxidative stress (2009), Tuberculosis, 89, S26-S32.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.4.12

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Mycolicibacterium smegmatis

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Mycolicibacterium smegmatis
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
13300
-
 calculated from amino acid sequence Mycolicibacterium smegmatis
15000
-
 SDS-PAGE Mycolicibacterium smegmatis

Organism

Organism UniProt Comment Textmining
Mycolicibacterium smegmatis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-methionine (R)-sulfoxide + thioredoxin
-
 Mycolicibacterium smegmatis L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase B
-
 Mycolicibacterium smegmatis
MsrB
-
 Mycolicibacterium smegmatis

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
 Mycolicibacterium smegmatis

General Information

General Information Comment Organism
malfunction the msrB mutant MSDELTAmsrB exhibits significantly lower intracellular survival than its wild type counterpart and shows no sensitivity to oxidants in vitro. The msrA/B double mutant (MSDELTAmsrA/B) exhibits a phenotype similar to that of msrA mutant in terms of both intracellular survival and sensitivity to oxidants Mycolicibacterium smegmatis
physiological function MsrB of plays only a limited role in resisting intracellular and in vitro reactive oxygen intermediates Mycolicibacterium smegmatis