Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,3-Bis(2-chloroethyl)-1-nitrosourea | - |
Cricetulus griseus | |
1,3-Bis(2-chloroethyl)-1-nitrosourea | - |
Homo sapiens | |
arsenite | - |
Cricetulus griseus | |
arsenite | - |
Homo sapiens | |
Phenylarsine oxide | - |
Cricetulus griseus | |
Phenylarsine oxide | complete inhibition at 1 mM | Homo sapiens | |
selenium oxide | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GSH + protein disulfide | Homo sapiens | - |
GSSG + protein-dithiol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
chinese hamster | - |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
insulinoma cell | - |
Homo sapiens | - |
lung | A549 carcinoma | Homo sapiens | - |
mammary gland | MCF7 carcinoma | Homo sapiens | - |
ovary | - |
Cricetulus griseus | - |
prostate gland | DU145 carcinoma | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
specific activities of different human carcinoma cell lines with different thiol and disulfide substrates | Homo sapiens |
0.0035 | - |
A549 carcinoma cells, substrates GSH, cystamine or cystine | Homo sapiens |
0.0075 | - |
A549 carcinoma cells, substrate dithiothreitol | Homo sapiens |
0.03 | - |
A549 carcinoma cells, substrate hydroxyethyl disulfide | Homo sapiens |
0.067 | - |
A549 carcinoma cells, substrate lipoate | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-lipoate + protein disulfide | - |
Homo sapiens | ? | - |
? | |
cysteamine + protein disulfide | low activity | Homo sapiens | ? | - |
? | |
dithiothreitol + protein disulfide | low activity | Homo sapiens | ? | - |
? | |
GSH + protein disulfide | - |
Homo sapiens | GSSG + protein-dithiol | - |
? | |
hydroxyethyl disulfide + protein disulfide | - |
Homo sapiens | ? | - |
? |