Literature summary for 1.8.4.9 extracted from

Chartron, J.; Carroll, K.S.; Shiau, C.; Gao, H.; Leary, J.A.; Bertozzi, C.R.; Stout, C.D.
Substrate recognition, protein dynamics, and iron-sulfur cluster in Pseudomonas aeruginosa adenosine 5-phosphosulfate reductase (2006), J. Mol. Biol., 364, 152-169.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging-drop vapour diffusion	Pseudomonas aeruginosa

Inhibitors

Inhibitors	Comment	Organism	Structure
5'-adenylylsulfate	when thioredoxin concentrations are limiting, elevated concentrations of APS result in inhibition	Pseudomonas aeruginosa

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0033	-	5'-adenylylsulfate	in the presence of 0.001 mM thioredoxin	Pseudomonas aeruginosa
0.0052	-	5'-adenylylsulfate	in the presence of 0.01 mM thioredoxin	Pseudomonas aeruginosa

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5'-adenylylsulfate + glutathione + glutathione	-	Pseudomonas aeruginosa	adenosine monophosphate + sulfite + oxidized glutathione	-	r

Subunits

Subunits	Comment	Organism
tetramer	-	Pseudomonas aeruginosa

Synonyms

Synonyms	Comment	Organism
adenosine 5-phosphosulfate reductase	-	Pseudomonas aeruginosa
APS reductase	-	Pseudomonas aeruginosa

Cofactor

Cofactor	Comment	Organism	Structure
thioredoxin	-	Pseudomonas aeruginosa

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0074	-	5'-adenylylsulfate	in the presence of 0.001 mM thioredoxin	Pseudomonas aeruginosa
0.081	-	5'-adenylylsulfate	in the presence of 0.01 mM thioredoxin	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)