Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.8.99.2 extracted from

  • Fritz, G.; Roth, A.; Schiffer, A.; Buchert, T.; Bourenkov, G.; Bartunik, H.D.; Huber, H.; Stetter, K.O.; Kroneck, P.M.H.; Ermler, U.
    Structure of adenylylsulfate reductase from the hyperthermophilic Archaeoglobus fulgidus at 1.6-A resolution (2002), Proc. Natl. Acad. Sci. USA, 99, 1836-1841.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.99.2

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Archaeoglobus fulgidus
the structures of the enzyme in the two-electron reduced state and with sulfite bound to FAD are reported at 1.6 A and 2.5 A resolution, respectively Archaeoglobus fulgidus

Metals/Ions

Metals/Ions Comment Organism Structure
4Fe-4S cluster flavoenzyme.The two electrons required for adenylyl sulfate reduction are transferred via two [4Fe-4S] clusters from the surface of the protein to FAD. The large difference in reduction potential of these clusters (-60 mV and -500 mV) can be explained by interactions of the clusters with the protein matrix Archaeoglobus fulgidus
Iron the two electrons required for the adenylyl sulfate reduction are transferred via two [4Fe-4S] clusters from the surface of the protein to FAD Archaeoglobus fulgidus

Organism

Organism UniProt Comment Textmining
Archaeoglobus fulgidus
-
-
-
Archaeoglobus fulgidus O28603
-
-

Reaction

Reaction Comment Organism Reaction ID
AMP + sulfite + acceptor = adenylyl sulfate + reduced acceptor catalysis involves a nucleophilic attack of the N5-atom of reduced FAD on the sulfur atom of the enzyme Archaeoglobus fulgidus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenylyl sulfate + reduced acceptor
-
 Archaeoglobus fulgidus AMP + sulfite + acceptor
-
 r
AMP + sulfite + acceptor
-
 Archaeoglobus fulgidus adenylyl sulfate + reduced acceptor
-
 r

Synonyms

Synonyms Comment Organism
adenosine 5'-phosphosulfate reductase
-
 Archaeoglobus fulgidus
APS reductase
-
 Archaeoglobus fulgidus

Cofactor

Cofactor Comment Organism Structure
FAD flavoenzyme.The two electrons required for adenylyl sulfate reduction are transferred via two [4Fe-4S] clusters from the surface of the protein to FAD Archaeoglobus fulgidus
flavin flavoenzyme Archaeoglobus fulgidus