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Literature summary for 2.1.1.1 extracted from

  • Kim, H.C.; Mofarrahi, M.; Vassilakopoulos, T.; Maltais, F.; Sigala, I.; Debigare, R.; Bellenis, I.; Hussain, S.N.
    Expression and functional significance of nicotinamide N-methyl transferase in skeletal muscles of patients with chronic obstructive pulmonary disease (2010), Am. J. Respir. Crit. Care Med., 181, 797-805.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
diaphragm
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Homo sapiens
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quadriceps
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Homo sapiens
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Synonyms

Synonyms Comment Organism
nicotinamide N-methyl transferase
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression is significantly elevated in the diaphragm and quadriceps muscles of patients with chronic obstructive pulmonary disease. The relative induction of expression is greater in the quadriceps muscle (10-fold) than it is in the diaphragm(2-fold). Expression correlates negatively with these verity of chronic obstructive pulmonary disease and limb muscle wasting. Expression in skeletal myoblasts is significantly induced by IL-6, transforming growth factor beta, and tumor necrosis factor-alpha. Overexpression in myoblasts triggers a significant increase in proliferation and migration, but has no influence on cell death up