Protein Variants | Comment | Organism |
---|---|---|
additional information | gain-of-function non-coding micro-RNA-1291 (miR-1291) transfected to PANC-1 cells lead to a significantly altered metabolome for the human pancreatic carcinoma cells, phenotype with a lower migration and invasion capacity as well as suppressed tumorigenesis in a xenograft tumor mouse model. A number of metabolites, including N-methylnicotinamide, involved in nicotinamide metabolism, and l-carnitine, isobutyryl-carnitine and isovaleryl-carnitine, involved in fatty acid metabolism, are elevated in miR-1291-expressing PANC-1. N-methylnicotinamide is elevated to the greatest extent associated with a sharp increase in nicotinamide N-methyltransferase (NNMT) mRNA level in miR-1291-expressing PANC-1 cells. The expression of NNMT mRNA is inversely correlated with pancreatic tumor size in the xenograft mouse model | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + nicotinamide | Homo sapiens | - |
S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PANC-1 cell | sharp increase in nicotinamide N-methyltransferase (NNMT) mRNA level in miR-1291-expressing PANC-1 cells at elevated N-methylnicotinamide levels | Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + nicotinamide | - |
Homo sapiens | S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NNMT | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | gain-of-function non-coding micro-RNA-1291 miR-1291-altered PANC-1 cell function is associated with the increase in N-methylnicotinamide level and NNMT expression | up |