Application | Comment | Organism |
---|---|---|
drug development | the enzyme might be a good molecular target for lung cancer therapy | Homo sapiens |
pharmacology | the enzyme might be a good molecular target for lung cancer therapy | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
quantitative real-time PCR enzyme expression analysis in non-smalll cell lung cancer samples | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + nicotinamide | Homo sapiens | - |
S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
additional information | quantitative real-time PCR enzyme expression analysis | Homo sapiens | - |
non-small cell lung cancer cell | the cells show enzyme overexpression compared to both tumor-adjacent and surrounding tissue | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
quantitative enzyme activity analysis in 25 non-smalll cell lung cancer samples | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + nicotinamide | - |
Homo sapiens | S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NNMT | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.6 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | shRNA-mediated gene silencing of NNMT leads to a significntl inhibition of cell proliferation and colony formation ability, downregulation of the enzyme significantly reduces the tumorigenicity of A-549 cells | Homo sapiens |
physiological function | role of nicotinamide N-methyltransferase in non-small cell lung cancer | Homo sapiens |