Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cd2+ | - |
Mus musculus | |
Cu2+ | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | no effect on enzyme activity by Fe2+ and Mn2+, but Mn2+ reduces mouse CD1 brain striatum neuronal cell survival with less than 10% cells surviving at 0.1 mM Mn2+ | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + nicotinamide | Mus musculus | - |
S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
neuronal cell | CD1 brain striatum neuronal cells | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + nicotinamide | - |
Mus musculus | S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NNMT | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.6 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | alterations in in vivo enzyme NNMT activity are believed to be negatively associated with gene polymorphism and environmental influences are also considered to be significant | Mus musculus |
additional information | nicotinamide and 1-methylnicotinamide are neurotoxic, chronic exposure to Mn2+ plays a role in idiopathic Parkinson's disease associated to 1-methylnicotinamide. But no metal-increased NNMT activity can be measured | Mus musculus |