Activating Compound | Comment | Organism | Structure |
---|---|---|---|
imipramine | slightly but significantly activates the mouse liver NNMT enzyme and also changes the kinetic parameters Vmax, Km and Ki | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | inhibition of NNMT activity is a promising therapeutic target for cancer therapy | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
nicotinamide | the enzyme shows substrate inhibition kinetics | Homo sapiens | |
nicotinamide | the enzyme shows substrate inhibition kinetics | Mus musculus | |
nicotinamide | the enzyme shows substrate inhibition kinetics | Oryctolagus cuniculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Michaelis-Menten kinetics | Mus musculus | |
additional information | - |
additional information | Michaelis-Menten kinetics | Homo sapiens | |
additional information | - |
additional information | Michaelis-Menten kinetics, the Km value cannot be determined using Michaelis-Menten kinetic modelling | Oryctolagus cuniculus | |
1.02 | - |
nicotinamide | pH 7.2, 37°C, liver homogenate | Mus musculus | |
1.36 | - |
nicotinamide | pH 7.2, 37°C, liver homogenate | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Oryctolagus cuniculus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | development and evaluation of a HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples, overview | ? | - |
? | |
additional information | Homo sapiens | development and evaluation of a HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples, overview | ? | - |
? | |
additional information | Oryctolagus cuniculus | development and evaluation of a HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples, overview | ? | - |
? | |
S-adenosyl-L-methionine + nicotinamide | Mus musculus | - |
S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? | |
S-adenosyl-L-methionine + nicotinamide | Homo sapiens | - |
S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? | |
S-adenosyl-L-methionine + nicotinamide | Oryctolagus cuniculus | - |
S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | development and evaluation of a HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples, overview | Mus musculus | ? | - |
? | |
additional information | development and evaluation of a HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples, overview | Homo sapiens | ? | - |
? | |
additional information | development and evaluation of a HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples, overview | Oryctolagus cuniculus | ? | - |
? | |
S-adenosyl-L-methionine + nicotinamide | - |
Mus musculus | S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? | |
S-adenosyl-L-methionine + nicotinamide | - |
Homo sapiens | S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? | |
S-adenosyl-L-methionine + nicotinamide | - |
Oryctolagus cuniculus | S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NNMT | - |
Mus musculus |
NNMT | - |
Homo sapiens |
NNMT | - |
Oryctolagus cuniculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Oryctolagus cuniculus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.02 | - |
nicotinamide | pH 7.2, 37°C, liver homogenate | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Mus musculus |
7.2 | - |
assay at | Homo sapiens |
7.2 | - |
assay at | Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Mus musculus | |
S-adenosyl-L-methionine | - |
Homo sapiens | |
S-adenosyl-L-methionine | - |
Oryctolagus cuniculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
3.57 | - |
nicotinamide | pH 7.2, 37°C, liver homogenate | Oryctolagus cuniculus | |
20.01 | - |
nicotinamide | pH 7.2, 37°C, liver homogenate | Homo sapiens | |
50.64 | - |
nicotinamide | pH 7.2, 37°C, liver homogenate | Mus musculus |