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Literature summary for 2.1.1.10 extracted from
- S-Adenosylmethionine:L-homocysteine S-methyltransferase (Saccharomyces cerevisiae) (1971), Methods Enzymol., 17B, 400-405.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 2-mercaptoethanol | increases activity at low substrate concentrations | Saccharomyces cerevisiae |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| L-methionine | no inhibition with D-isomer; product inhibition | Saccharomyces cerevisiae | |
| N-Hydroxymethyl-DL-methionine | - |
Saccharomyces cerevisiae | |
| S-adenosyl-L-homocysteine | product inhibition | Saccharomyces cerevisiae | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cd2+ | activating | Saccharomyces cerevisiae | |
| Zn2+ | activating | Saccharomyces cerevisiae | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 30000 | - |
from sedimentation coefficient | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + L-homocysteine | Rattus norvegicus | - |
S-adenosyl-L-homocysteine + L-methionine | - |
? | |
| S-adenosyl-L-methionine + L-homocysteine | Saccharomyces cerevisiae | - |
S-adenosyl-L-homocysteine + L-methionine | - |
? | |
| S-adenosyl-L-methionine + L-homocysteine | Klebsiella aerogenes | - |
S-adenosyl-L-homocysteine + L-methionine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Klebsiella aerogenes | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Saccharomyces cerevisiae |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.37 | - |
purified enzyme, S-adenosyl-L-methionine as methyl donor | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-ethionine + L-homocysteine | - |
Saccharomyces cerevisiae | S-adenosyl-L-homocysteine + L-ethionine | - |
? | |
| S-adenosyl-L-methionine + D-homocysteine | - |
Saccharomyces cerevisiae | ? | - |
? | |
| S-adenosyl-L-methionine + L-homocysteine | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + L-methionine | - |
? | |
| S-adenosyl-L-methionine + L-homocysteine | - |
Saccharomyces cerevisiae | S-adenosyl-L-homocysteine + L-methionine | - |
? | |
| S-adenosyl-L-methionine + L-homocysteine | - |
Klebsiella aerogenes | S-adenosyl-L-homocysteine + L-methionine | - |
? | |
| S-adenosyl-L-methionine + L-homocysteine thiolactone | - |
Saccharomyces cerevisiae | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8 | - |
Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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