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Literature summary for 2.1.1.100 extracted from

  • Stephenson, R.C.; Clarke, S.
    Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate (1990), J. Biol. Chem., 265, 16248-16254.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
S-adenosyl-L-homocysteine
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0021
-
S-adenosyl-L-methionine
-
Rattus norvegicus
0.0022
-
S-farnesyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
Rattus norvegicus
0.0109
-
S-geranylgeranyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
Rattus norvegicus
0.389
-
S-geranyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
Rattus norvegicus
0.48
-
S-decyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
Rattus norvegicus
0.64
-
S-tridecyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
Rattus norvegicus
1.12
-
S-pentadecyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
Rattus norvegicus
1.76
-
S-octyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Storage Stability

Storage Stability Organism
-70°C, 6 months Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine enzyme can methylate both peptides and proteins Rattus norvegicus S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
-
?
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine methyl esterification of proteins containing a C-terminal-CXXX sequence requires not only the removal of the 3 terminal amino acids but the isoprenylation of the sulfhydryl group as well Rattus norvegicus S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
-
?
S-adenosylmethionine + S-decyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
Rattus norvegicus S-adenosylhomocysteine + S-decyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
-
?
S-adenosylmethionine + S-farnesyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
Rattus norvegicus S-adenosylhomocysteine + S-farnesyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
-
?
S-adenosylmethionine + S-geranyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
Rattus norvegicus S-adenosylhomocysteine + S-geranyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
-
?
S-adenosylmethionine + S-geranylgeranyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
Rattus norvegicus S-adenosylhomocysteine + S-geranylgeranyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
-
?
S-adenosylmethionine + S-octyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
Rattus norvegicus S-adenosylhomocysteine + S-octyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
-
?
S-adenosylmethionine + S-pentadecyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
Rattus norvegicus S-adenosylhomocysteine + S-pentadecyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
-
?
S-adenosylmethionine + S-tridecyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
Rattus norvegicus S-adenosylhomocysteine + S-tridecyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
5.6 8.6
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0092
-
S-adenosyl-L-homocysteine
-
Rattus norvegicus