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Literature summary for 2.1.1.100 extracted from

  • Pillinger, M.H.; Volker, C.; Stock, J.B.; Weissmann, G.; Philips, M.R.
    Characterization of a plasma membrane-associated prenylcysteine-directed a carboxyl methyltransferase in human neutrophils (1994), J. Biol. Chem., 269, 1486-1492.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
formyl-methionine-leucine-phenylalanine stimulation of carboxyl methylation of GTP-binding proteins through a substrate-dependent mechanism Homo sapiens

General Stability

General Stability Organism
complete loss of activity after exposure to detergent e.g. CHAPS, octyl-beta-glucoside and sodium deoxycholate, activity can be reconstituted by removal of the detergent in the presence of phospholipid Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5'-deoxymethylthioadenosine
-
Homo sapiens
S-adenosyl-L-homocysteine
-
Homo sapiens
sinefungin
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0013
-
S-adenosyl-L-methionine
-
Homo sapiens
0.0014
-
N-acetyl-S-geranylgeranyl-L-cysteine
-
Homo sapiens
0.0116
-
N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Homo sapiens
-
neutrophil light membrane fraction Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + N-acetyl-S-geranylgeranyl-L-cysteine
-
Homo sapiens S-adenosyl-L-homocysteine + N-acetyl-S-geranylgeranyl-L-cysteine methyl ester
-
?
S-adenosylmethionine + N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
Homo sapiens S-adenosylhomocysteine + N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00007
-
sinefungin
-
Homo sapiens
0.00157
-
S-adenosyl-L-homocysteine
-
Homo sapiens
3.95
-
5'-deoxymethylthioadenosine
-
Homo sapiens