Cloned (Comment) | Organism |
---|---|
expressed in Sf9 insect cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3,5-difluoro-4-methoxyphenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine | - |
Homo sapiens | |
(3-chloro-4-fluorophenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine | - |
Homo sapiens | |
(3-chlorophenyl)-[2-(2,2-dimethyl-4-thiophen-2-yltetrahydropyran-4-yl)ethyl]amine | - |
Homo sapiens | |
(4-chloro-3-fluorophenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine | - |
Homo sapiens | |
(5-chloro-2-fluorophenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine | - |
Homo sapiens | |
1-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-3-(3-fluorophenyl)thiourea | - |
Homo sapiens | |
1-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-3-(3-methoxphenyl)urea | - |
Homo sapiens | |
1-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-3-(3-methoxyphenyl)thiourea | - |
Homo sapiens | |
1-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-3-phenylthiourea | - |
Homo sapiens | |
1-(3-chlorophenyl)-3-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)thiourea | - |
Homo sapiens | |
1-(3-chlorophenyl)-3-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)urea | - |
Homo sapiens | |
2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-N-(3-methoxyphenyl)acetamide | - |
Homo sapiens | |
2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-N-phenylacetamide | - |
Homo sapiens | |
2-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl](phenyl)amino]-1-(furan-2-yl)ethanone | - |
Homo sapiens | |
3,4-dichloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2Hpyran-4-yl)ethyl]aniline | - |
Homo sapiens | |
3,5-dichloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline | - |
Homo sapiens | |
3-chloro-4-methyl-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)ethyl]aniline | - |
Homo sapiens | |
3-chloro-4-methyl-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]aniline | - |
Homo sapiens | |
3-chloro-N-(3-chlorophenyl)-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydropyran-4-yl)ethyl]aniline | - |
Homo sapiens | |
3-chloro-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)-ethyl]aniline | - |
Homo sapiens | |
3-chloro-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydrothiopyran-4-yl)ethyl]aniline | - |
Homo sapiens | |
3-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-4-methylaniline | - |
Homo sapiens | |
3-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline | - |
Homo sapiens | |
3-chloro-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline | - |
Homo sapiens | |
3-fluoro-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)-ethyl]aniline | - |
Homo sapiens | |
3-fluoro-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline | - |
Homo sapiens | |
3-methoxy-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)-ethyl]aniline | - |
Homo sapiens | |
3-methoxy-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydropyran-4-yl)ethyl]aniline | - |
Homo sapiens | |
3-methoxy-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydrothiopyran-4-yl)ethyl]aniline | - |
Homo sapiens | |
3-methoxy-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline | - |
Homo sapiens | |
3-methoxy-N-[2-[4-(4-methoxyphenyl)-2,2-dimethyltetrahydro-2H-pyran-4-yl]ethyl]aniline | - |
Homo sapiens | |
3-methyl-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline | - |
Homo sapiens | |
3-tert-butyl-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline | - |
Homo sapiens | |
3-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethylamino]benzoic acid | - |
Homo sapiens | |
3-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethylamino]phenol | - |
Homo sapiens | |
3-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]-N,N-dimethylbenzenesulfonamide | - |
Homo sapiens | |
3-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]benzonitrile | - |
Homo sapiens | |
4-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-3-methylaniline | - |
Homo sapiens | |
4-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline | - |
Homo sapiens | |
4-tert-butyl-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline | - |
Homo sapiens | |
4-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]benzenesulfonamide | - |
Homo sapiens | |
4-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]benzonitrile | - |
Homo sapiens | |
cysmethynil | relatively potent in vitro inhibitor | Homo sapiens | |
ethyl 4-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]amino]benzoate | - |
Homo sapiens | |
FTI-2628 | - |
Homo sapiens | |
N'-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N,N-dimethylbenzene-1,3-diamine | - |
Homo sapiens | |
N-(3-chlorophenyl)-2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)acetamide | - |
Homo sapiens | |
N-(3-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]phenyl)acetamide | - |
Homo sapiens | |
N-benzyl-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]furan-2-carboxamide | - |
Homo sapiens | |
N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydropyran-4-yl)-ethyl]aniline | - |
Homo sapiens | |
N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydrothiopyran-4-yl)ethyl]aniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-2-methylaniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3,4-dimethoxyaniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3,5-dimethylaniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-(trifluoromethoxy)aniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-(trifluoromethyl)aniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-ethylaniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-fluoroaniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-isopropylaniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-methoxy-4-methylaniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-methoxyaniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-methylaniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-(trifluoromethoxy)aniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-fluoroaniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-isopropylaniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-methoxyaniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-methylaniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N,3-dimethylaniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N-methylaniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N-phenylacetamide | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]aniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-3,4-dimethylaniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-3-nitroaniline | - |
Homo sapiens | |
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-4-nitroaniline | - |
Homo sapiens | |
N-[3-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-3-(2-methoxyphenyl)propyl]-N-(4-methoxybenzyl)furan-2-carboxamide | the inhibitor is competitive with respect to a prenylated methyl acceptor substrate but noncompetitive toward the S-adenosyl-L-methionine | Homo sapiens | |
[2-(2,2-dimethyl-4-p-tolyltetrahydropyran-4-yl)ethyl]-(3-methoxyphenyl)amine | - |
Homo sapiens | |
[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-(2-fluorophenyl)amine | - |
Homo sapiens | |
[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]-(2-fluoro-4-methylphenyl)amine | - |
Homo sapiens | |
[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]-(3-fluoro-4-methoxyphenyl)amine | - |
Homo sapiens | |
[2-(2,2-dimethyl-4-thiophen-2-yltetrahydropyran-4-yl)-ethyl]-(3-methoxyphenyl)amine | - |
Homo sapiens | |
[2-(2,2-dimethyl-4-thiophen-2-yltetrahydropyran-4-yl)-ethyl]phenylamine | - |
Homo sapiens | |
[2-[4-(3-chlorophenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine | - |
Homo sapiens | |
[2-[4-(3-fluoro-phenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine | - |
Homo sapiens | |
[2-[4-(4-chlorophenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine | - |
Homo sapiens | |
[2-[4-(4-fluorophenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
DU-145 cell | - |
Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + N-acetyl-S-geranylgeranyl-L-cysteine | - |
Homo sapiens | S-adenosyl-L-homocysteine + N-acetyl-S-geranylgeranyl-L-cysteine methyl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Icmt | - |
Homo sapiens |
isoprenylcysteine carboxyl methyltransferase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000013 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-methoxy-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydropyran-4-yl)ethyl]aniline | |
0.0000038 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | (3-chlorophenyl)-[2-(2,2-dimethyl-4-thiophen-2-yltetrahydropyran-4-yl)ethyl]amine | |
0.000008 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | [2-[4-(3-fluoro-phenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine | |
0.000015 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-methoxyaniline | |
0.000015 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydropyran-4-yl)-ethyl]aniline | |
0.000019 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | [2-(2,2-dimethyl-4-thiophen-2-yltetrahydropyran-4-yl)-ethyl]-(3-methoxyphenyl)amine | |
0.000025 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline | |
0.000025 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | (3-chloro-4-fluorophenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine | |
0.000026 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-3-nitroaniline | |
0.000031 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-methylaniline | |
0.000031 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-methylaniline | |
0.000031 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | (3,5-difluoro-4-methoxyphenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine | |
0.000032 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | (5-chloro-2-fluorophenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine | |
0.00004 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-ethylaniline | |
0.000049 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-4-methylaniline | |
0.000052 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-fluoroaniline | |
0.000054 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3,5-dimethylaniline | |
0.000066 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]benzonitrile | |
0.000069 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-3,4-dimethylaniline | |
0.00009 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-methoxy-4-methylaniline | |
0.00009 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-(trifluoromethoxy)aniline | |
0.0001 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | [2-[4-(4-fluorophenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine | |
0.00012 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-benzyl-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]furan-2-carboxamide | |
0.000123 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 4-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]benzonitrile | |
0.000131 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N'-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N,N-dimethylbenzene-1,3-diamine | |
0.000132 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-isopropylaniline | |
0.00016 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | [2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]-(3-fluoro-4-methoxyphenyl)amine | |
0.000167 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-isopropylaniline | |
0.000168 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-fluoroaniline | |
0.00017 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3,5-dichloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline | |
0.000181 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3,4-dichloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2Hpyran-4-yl)ethyl]aniline | |
0.000184 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-(trifluoromethoxy)aniline | |
0.00019 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | [2-[4-(3-chlorophenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine | |
0.00027 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-methoxyaniline | |
0.00027 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | [2-(2,2-dimethyl-4-thiophen-2-yltetrahydropyran-4-yl)-ethyl]phenylamine | |
0.0003 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | [2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]-(2-fluoro-4-methylphenyl)amine | |
0.000308 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 4-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-3-methylaniline | |
0.00031 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 2-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl](phenyl)amino]-1-(furan-2-yl)ethanone | |
0.00036 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 4-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline | |
0.00038 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-(trifluoromethyl)aniline | |
0.00042 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-methoxy-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydrothiopyran-4-yl)ethyl]aniline | |
0.00046 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-chloro-4-methyl-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]aniline | |
0.00047 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | (4-chloro-3-fluorophenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine | |
0.00055 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | [2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-(2-fluorophenyl)amine | |
0.000556 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-tert-butyl-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline | |
0.00063 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | [2-[4-(4-chlorophenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine | |
0.000652 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3,4-dimethoxyaniline | |
0.000682 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-4-nitroaniline | |
0.00076 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 4-tert-butyl-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline | |
0.000777 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-methoxy-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline | |
0.001 | - |
IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydrothiopyran-4-yl)ethyl]aniline | |
0.001 | - |
IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-methoxy-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)-ethyl]aniline | |
0.001 | - |
IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-chloro-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)-ethyl]aniline | |
0.001 | - |
IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-fluoro-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)-ethyl]aniline | |
0.001 | - |
IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-chloro-4-methyl-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)ethyl]aniline | |
0.001 | - |
IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 1-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-3-(3-methoxphenyl)urea | |
0.001 | - |
IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 1-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-3-phenylthiourea | |
0.001 | - |
IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 1-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-3-(3-fluorophenyl)thiourea | |
0.00135 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-(3-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]phenyl)acetamide | |
0.00234 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N-phenylacetamide | |
0.00249 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-chloro-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydrothiopyran-4-yl)ethyl]aniline | |
0.0027 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]aniline | |
0.00288 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | ethyl 4-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]amino]benzoate | |
0.00325 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-methyl-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline | |
0.00325 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-fluoro-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline | |
0.0035 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[3-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-3-(2-methoxyphenyl)propyl]-N-(4-methoxybenzyl)furan-2-carboxamide | |
0.0036 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-2-methylaniline | |
0.00383 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]-N,N-dimethylbenzenesulfonamide | |
0.00383 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-chloro-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline | |
0.00419 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | [2-(2,2-dimethyl-4-p-tolyltetrahydropyran-4-yl)ethyl]-(3-methoxyphenyl)amine | |
0.005 | - |
IC50 above 0.005 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethylamino]phenol | |
0.005 | - |
IC50 above 0.005 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethylamino]benzoic acid | |
0.005 | - |
IC50 above 0.005 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-chloro-N-(3-chlorophenyl)-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydropyran-4-yl)ethyl]aniline | |
0.005 | - |
IC50 above 0.005 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-N-phenylacetamide | |
0.005 | - |
IC50 above 0.005 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-N-(3-methoxyphenyl)acetamide | |
0.005 | - |
IC50 above 0.005 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-(3-chlorophenyl)-2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)acetamide | |
0.00985 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N,3-dimethylaniline | |
0.01 | - |
IC50 above 0.01 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N-methylaniline | |
0.0125 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 3-methoxy-N-[2-[4-(4-methoxyphenyl)-2,2-dimethyltetrahydro-2H-pyran-4-yl]ethyl]aniline | |
0.0131 | - |
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 4-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]benzenesulfonamide | |
1 | - |
IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 1-(3-chlorophenyl)-3-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)urea | |
1 | - |
IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 1-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-3-(3-methoxyphenyl)thiourea | |
1 | - |
IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C | Homo sapiens | 1-(3-chlorophenyl)-3-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)thiourea |