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Literature summary for 2.1.1.101 extracted from
- Properties of S-adenosyl-L-methionine:macrocin O-methyltransferase in extracts of Streptomyces fradiae strains which produce normal or elevated levels of tylosin and in mutants blocked in specific O-methylations (1981), Antimicrob. Agents Chemother., 20, 370-377.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| macrocin | - |
Streptomyces fradiae |  |
| tylosin | - |
Streptomyces fradiae | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required for maximal activity | Streptomyces fradiae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + macrocin | Streptomyces fradiae | terminal and main rate-limiting step in tylosin biosynthesis | S-adenosylhomocysteine + tylosin | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces fradiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + macrocin | - |
Streptomyces fradiae | S-adenosyl-L-homocysteine + tylosin | - |
? | |
| S-adenosyl-L-methionine + macrocin | terminal and main rate-limiting step in tylosin biosynthesis | Streptomyces fradiae | S-adenosylhomocysteine + tylosin | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 31 | - |
- |
Streptomyces fradiae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8.2 | - |
Streptomyces fradiae |
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