Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.103 extracted from

  • Pessi, G.; Kociubinski, G.; Mamoun, C.B.
    A pathway for phosphatidylcholine biosynthesis in Plasmodium falciparum involving phosphoethanolamine methylation (2004), Proc. Natl. Acad. Sci. USA, 101, 6206-6211.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.103

Cloned(Commentary)

Cloned (Comment) Organism
via RNA isolated from different blood stages Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
miltefosine 50% inhibition at 0.05 mM, 90% inhibition at 0.1 mM Plasmodium falciparum
additional information not inhibitory: clofibric acid Plasmodium falciparum
phosphocholine product inhibition, 50% inhibition at 0.05 mM Plasmodium falciparum
S-adenosyl-L-homocysteine 50% inhibition at 0.05 mM Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.079
-
 Ethanolamine phosphate pH 8.6, 37°C Plasmodium falciparum
0.153
-
 S-adenosyl-L-methionine pH 8.6, 37°C Plasmodium falciparum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
31000
-
 x * 31000, calculated Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Plasmodium falciparum enzyme is involved in biosynthesis of phosphatidylcholine via phosphoethanolamine methylation. Model of pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q6T755 expression in Escherichia coli
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme is involved in biosynthesis of phosphatidylcholine via phosphoethanolamine methylation. Model of pathway Plasmodium falciparum ?
-
 ?
S-adenosyl-L-methionine + ethanolamine phosphate
-
 Plasmodium falciparum S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 31000, calculated Plasmodium falciparum
More monopartite enzyme with a single catalytic domain Plasmodium falciparum

Synonyms

Synonyms Comment Organism
Pfpmt
-
 Plasmodium falciparum

pI Value

Organism Comment pI Value Maximum pI Value
Plasmodium falciparum calculated
-
 5.42