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Literature summary for 2.1.1.106 extracted from
- Formation of 2-methyltryptophan in the biosynthesis of thiostrepton: isolation of S-adenosyl-methionine:tryptophan 2-methyltransferase (1990), Arch. Biochem. Biophys., 278, 35-40.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-Methyltryptophan | product inhibition | Streptomyces laurentii |  |
| S-adenosyl-L-homocysteine | - |
Streptomyces laurentii | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.12 | - |
S-adenosyl-L-methionine | cell free extract | Streptomyces laurentii | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | possibly loosely membrane-bound | Streptomyces laurentii | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces laurentii | - |
- |
- |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, 1 d, loss of 80% activity | Streptomyces laurentii |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + D,L-tryptophan | significant slower reaction rate with D-tryptophan | Streptomyces laurentii | S-adenosyl-L-homocysteine + D,L-2-methyltryptophan | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | - |
- |
Streptomyces laurentii |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
half-life: 2 h | Streptomyces laurentii |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
cell free extract | Streptomyces laurentii |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | 9 | half-maximal activity at pH 6.8 and pH 9.0 | Streptomyces laurentii |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.48 | - |
S-adenosyl-L-homocysteine | - |
Streptomyces laurentii | |
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Release 2023.1 (January 2023)
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