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Literature summary for 2.1.1.13 extracted from

  • Elshihawy, H.; Helal, M.A.; Said, M.; Hammad, M.A.
    Design, synthesis, and enzyme kinetics of novel benzimidazole and quinoxaline derivatives as methionine synthase inhibitors (2014), Bioorg. Med. Chem., 22, 550-558.
    View publication on PubMed
Search for more literature for 2.1.1.13

Crystallization (Commentary)

Crystallization (Comment) Organism
docking studies for inhibitors 4-(7-nitroquinoxalin-2-yl)benzoic acid, N-[(5-nitro-1H-benzimidazol-2-yl)methyl]benzamide, and 4-nitro-N-[2-(5-nitro-1H-benzimidazol-2-yl)ethyl]benzamide. Polar residues within the binding site of 5-methyltetrahydrofolate, namely, Asn404, Asn458, Asp525, Asn567, and Arg579, are critical for the interaction with substrate Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
4-(7-nitroquinoxalin-2-yl)benzoic acid mixed inhibition type Rattus norvegicus
4-nitro-N-[2-(5-nitro-1H-benzimidazol-2-yl)ethyl]benzamide competitive inhibition Rattus norvegicus
N-[(5-nitro-1H-benzimidazol-2-yl)methyl]benzamide mixed inhibition type Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q9Z2Q4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.009
-
 pH 7.4, 37°C Rattus norvegicus 4-(7-nitroquinoxalin-2-yl)benzoic acid
0.018
-
 pH 7.4, 37°C Rattus norvegicus 4-nitro-N-[2-(5-nitro-1H-benzimidazol-2-yl)ethyl]benzamide
0.02
-
 pH 7.4, 37°C Rattus norvegicus N-[(5-nitro-1H-benzimidazol-2-yl)methyl]benzamide