Literature summary for 2.1.1.137 extracted from

Walton, F.S.; Waters, S.B.; Jolley, S.L.; LeCluyse, E.L.; Thomas, D.J.; Styblo, M.
Selenium compounds modulate the activity of recombinant rat AsIII-methyltransferase and the methylation of arsenite by rat and human hepatocytes (2003), Chem. Res. Toxicol., 16, 261-265.

Search for more literature for 2.1.1.137

Activating Compound

Activating Compound	Comment	Organism	Structure
dimethylselenoxide	weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes	Homo sapiens
dimethylselenoxide	weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes	Rattus norvegicus
trimethyl-selenonium iodide	weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes	Homo sapiens
trimethylselenonium iodide	weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
dimethylselenoxide	weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes	Homo sapiens
dimethylselenoxide	weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes	Rattus norvegicus
methylselenic acid	-	Homo sapiens
methylselenic acid	-	Rattus norvegicus
Sodium selenite	-	Homo sapiens
Sodium selenite	-	Rattus norvegicus
trimethyl-selenonium iodide	weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes	Homo sapiens
trimethylselenonium iodide	weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	-	Homo sapiens	-
hepatocyte	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + arsenite	-	Homo sapiens	S-adenosyl-L-homocysteine + methylarsonate	-	?
S-adenosyl-L-methionine + arsenite	-	Rattus norvegicus	S-adenosyl-L-homocysteine + methylarsonate	-	?
S-adenosyl-L-methionine + methylarsonite	-	Homo sapiens	S-adenosyl-L-homocysteine + dimethylarsinate	-	?
S-adenosyl-L-methionine + methylarsonite	-	Rattus norvegicus	S-adenosyl-L-homocysteine + dimethylarsinate	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0014	-	Sodium selenite	-	Rattus norvegicus
0.0194	-	methylselenic acid	-	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)