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Literature summary for 2.1.1.137 extracted from
- A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol (2002), J. Biol. Chem., 277, 10795-10803.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9HBK9 | - |
- |
| Rattus norvegicus | Q8VHT6 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Rattus norvegicus | - |
| brain | - |
Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| Hep-G2 cell | mRNA is detected after 35 or 45 cycles of amplification | Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| lung | - |
Rattus norvegicus | - |
| additional information | not detected in UROtsa cells, an immortalized cell line derived from normal human urothelium, after 45 cycles of amplification | Homo sapiens | - |
| urinary bladder | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.00149 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + arsenite | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + methylarsonate | - |
? |  |
| S-adenosyl-L-methionine + methylarsonite | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + dimethylarsinate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AdoMet:arsenic(III) methyltransferase | - |
Rattus norvegicus |
| Cyr19 | - |
Rattus norvegicus |
| S-adenosyl-L-methionine:arsenic(III) methyltransferase | - |
Rattus norvegicus |
| S-adenosyl-L-methionine:arsenic(III) methyltransferase | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9.5 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 11 | pH 7.5: about 40% of maximal activity, pH 11: about 35% of maximal activity | Rattus norvegicus |
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Release 2023.1 (January 2023)
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