Literature summary for 2.1.1.14 extracted from

Saint-Macary, M.E.; Barbisan, C.; Gagey, M.J.; Frelin, O.; Beffa, R.; Lebrun, M.H.; Droux, M.
Methionine biosynthesis is essential for infection in the rice blast fungus Magnaporthe oryzae (2015), PLoS ONE, 10, e0111108.

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Organism

Organism	UniProt	Comment	Textmining
Pyricularia oryzae	-	-	-

Synonyms

Synonyms	Comment	Organism
Met6	-	Pyricularia oryzae

General Information

General Information	Comment	Organism
physiological function	on minimum medium, MET6 null mutants are auxotrophic for methionine. Even when grown in presence of excess methionine, mutants display developmental defects, such as reduced mycelium pigmentation, aerial hypha formation and sporulation, and metabolic signatures such as increased levels of cysteine, cystathionine, homocysteine, S-adenosylmethionine, S-adenosylhomocysteine while methionine and glutathione levels remain unchanged. the null mutant shows over-expression of CBS1 involved in the reversed transsulfuration pathway that metabolizes homocysteine into cysteine and SAM1 and SAHH1 involved in the methyl cycle. MET6 null mutants are non-pathogenic on both barley and rice leaves, and are defective in appressorium-mediated penetration and invasive infectious growth	Pyricularia oryzae

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Release 2023.1 (January 2023)