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Literature summary for 2.1.1.148 extracted from

  • Giladi, M.; Bitan-Banin, G.; Mevarech, M.; Ortenberg, R.
    Genetic evidence for a novel thymidylate synthase in the halophilic archaeon Halobacterium salinarum and in Campylobacter jejuni (2002), FEMS Microbiol. Lett., 216, 105-109.
    View publication on PubMed
Search for more literature for 2.1.1.148

Cloned(Commentary)

Cloned (Comment) Organism
complemetation of Escherichia coli thyA deletion mutant, transformants are able to grow in the absence of thymidine under oxygen limited conditions Campylobacter jejuni
complemetation of Haloferax volcanii thyA deletion mutant, transformants are able to grow in the absence of thymidine Halobacterium salinarum

Inhibitors

Inhibitors Comment Organism Structure
O2
-
 Campylobacter jejuni

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
23800
-
 SDS-PAGE Campylobacter jejuni

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP + FADH2 Halobacterium salinarum
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Campylobacter jejuni
-
 dTMP + tetrahydrofolate + FAD
-
 ?

Organism

Organism UniProt Comment Textmining
Campylobacter jejuni
-
-
-
Halobacterium salinarum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
from transformed E. coli Campylobacter jejuni

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Halobacterium salinarum dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Campylobacter jejuni dTMP + tetrahydrofolate + FAD
-
 ?