Activating Compound | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Helicobacter pylori | |
NADH | required to reduce bound FAD | Dictyostelium discoideum | |
NADH | required to reduce bound FAD | Thermotoga maritima | |
NADPH | - |
Helicobacter pylori | |
NADPH | required to reduce bound FAD | Dictyostelium discoideum | |
NADPH | required to reduce bound FAD | Thermotoga maritima |
Application | Comment | Organism |
---|---|---|
medicine | promising medical target, thyX is present in a number of pathogenic bacteria but absent in human | Chlamydia trachomatis |
medicine | promising medical target, thyX is present in a number of pathogenic bacteria but absent in human | Mycobacterium avium |
medicine | promising medical target, thyX is present in a number of pathogenic bacteria but absent in human | Rhodococcus sp. |
medicine | promising medical target, thyX is present in a number of pathogenic bacteria but absent in human | Clostridium perfringens |
medicine | promising medical target, thyX is present in a number of pathogenic bacteria but absent in human | Mycobacterium tuberculosis variant bovis |
medicine | promising medical target, thyX is present in a number of pathogenic bacteria but absent in human | Clostridium botulinum |
medicine | promising medical target, thyX is present in a number of pathogenic bacteria but absent in human | Clostridioides difficile |
medicine | promising medical target, thyX is present in a number of pathogenic bacteria but absent in human | Corynebacterium diphtheriae |
medicine | promising medical target, thyX is present in a number of pathogenic bacteria but absent in human | Treponema denticola |
medicine | promising medical target, thyX is present in a number of pathogenic bacteria but absent in human | Treponema pallidum |
medicine | promising medical target, thyX is present in a number of pathogenic bacteria but absent in human | Rickettsia prowazekii |
medicine | promising medical target, thyX is present in a number of pathogenic bacteria but absent in human | Borreliella burgdorferi |
medicine | promising medical target, thyX is present in a number of pathogenic bacteria but absent in human | Campylobacter jejuni |
medicine | promising medical target, thyX is present in a number of pathogenic bacteria but absent in human | Chlamydia pneumoniae |
medicine | promising medical target, thyX is present in a number of pathogenic bacteria but absent in human | Chlamydia psittaci |
medicine | promising medical target, thyX is present in a number of pathogenic bacteria but absent in human | Helicobacter pylori |
medicine | promising medical target, thyX is present in a number of pathogenic bacteria but absent in human | Bacillus anthracis |
medicine | promising medical target, thyX is present in a number of pathogenic bacteria but absent in human | Rickettsia conorii |
medicine | promising medical target, thyX is present in a number of pathogenic bacteria but absent in human | Ehrlichia chaffeensis |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 | Chlamydia trachomatis |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 | Mycobacterium avium |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 | Mycobacterium leprae |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 | Mycobacterium tuberculosis |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 | Helicobacter pylori |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 | Rhodococcus sp. |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 | Clostridium perfringens |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 | Mycobacterium tuberculosis variant bovis |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 | Treponema denticola |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 | Treponema pallidum |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 | Rickettsia prowazekii |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 | Borreliella burgdorferi |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 | Campylobacter jejuni |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 | Chlamydia pneumoniae |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 | Chlamydia psittaci |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 | Bacillus anthracis |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 | Rickettsia conorii |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 | Ehrlichia chaffeensis |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low crossreactivity against mammalian thyA enzymes, EC 2.1.1.45 | Clostridium botulinum |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low crossreactivity against mammalian thyA enzymes, EC 2.1.1.45 | Clostridioides difficile |
medicine | specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low crossreactivity against mammalian thyA enzymes, EC 2.1.1.45 | Corynebacterium diphtheriae |
Cloned (Comment) | Organism |
---|---|
- |
Thermotoga maritima |
Crystallization (Comment) | Organism |
---|---|
- |
Thermotoga maritima |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Thermotoga maritima | |
HEPES | - |
Thermotoga maritima |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Chlamydia trachomatis | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Dictyostelium discoideum | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Mycobacterium avium | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Mycobacterium leprae | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Mycobacterium tuberculosis | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Rhodococcus sp. | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Clostridium perfringens | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Mycobacterium tuberculosis variant bovis | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Clostridium botulinum | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Clostridioides difficile | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Corynebacterium diphtheriae | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Treponema denticola | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Treponema pallidum | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Rickettsia prowazekii | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Borreliella burgdorferi | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Campylobacter jejuni | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Chlamydia pneumoniae | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Chlamydia psittaci | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Helicobacter pylori | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Thermotoga maritima | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Bacillus anthracis | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Rickettsia conorii | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Ehrlichia chaffeensis | - |
dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | Thermotoga maritima DSM 3109 | - |
dTMP + tetrahydrofolate + FAD | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus anthracis | - |
- |
- |
Borreliella burgdorferi | - |
- |
- |
Campylobacter jejuni | - |
- |
- |
Chlamydia pneumoniae | - |
- |
- |
Chlamydia psittaci | - |
- |
- |
Chlamydia trachomatis | - |
- |
- |
Clostridioides difficile | - |
- |
- |
Clostridium botulinum | - |
- |
- |
Clostridium perfringens | - |
- |
- |
Corynebacterium diphtheriae | - |
- |
- |
Dictyostelium discoideum | - |
- |
- |
Ehrlichia chaffeensis | - |
- |
- |
Helicobacter pylori | - |
- |
- |
Helicobacter pylori | Q9ZJ93 | - |
- |
Mycobacterium avium | - |
- |
- |
Mycobacterium leprae | - |
- |
- |
Mycobacterium leprae | - |
simultaneous occurrence of thyA and thyX | - |
Mycobacterium tuberculosis | - |
- |
- |
Mycobacterium tuberculosis | - |
simultaneous occurrence of thyA and thyX | - |
Mycobacterium tuberculosis variant bovis | - |
- |
- |
Rhodococcus sp. | - |
- |
- |
Rickettsia conorii | - |
- |
- |
Rickettsia prowazekii | - |
- |
- |
Thermotoga maritima | Q9WYT0 | - |
- |
Thermotoga maritima | Q9WYT0 | TM0449 | - |
Thermotoga maritima DSM 3109 | Q9WYT0 | TM0449 | - |
Treponema denticola | - |
- |
- |
Treponema pallidum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Thermotoga maritima |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Chlamydia trachomatis | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Dictyostelium discoideum | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Mycobacterium avium | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Mycobacterium leprae | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Mycobacterium tuberculosis | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Helicobacter pylori | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Rhodococcus sp. | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Clostridium perfringens | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Mycobacterium tuberculosis variant bovis | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Clostridium botulinum | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Clostridioides difficile | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Corynebacterium diphtheriae | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Treponema denticola | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Treponema pallidum | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Rickettsia prowazekii | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Borreliella burgdorferi | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Campylobacter jejuni | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Chlamydia pneumoniae | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Chlamydia psittaci | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Thermotoga maritima | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Bacillus anthracis | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Rickettsia conorii | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Ehrlichia chaffeensis | dTMP + tetrahydrofolate + FAD | - |
? | |
5,10-methylenetetrahydrofolate + dUMP + FADH2 | - |
Thermotoga maritima DSM 3109 | dTMP + tetrahydrofolate + FAD | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | - |
Helicobacter pylori |
tetramer | data from crystal structure | Thermotoga maritima |
Synonyms | Comment | Organism |
---|---|---|
complementing thymidylate synthase | - |
Chlamydia trachomatis |
complementing thymidylate synthase | - |
Mycobacterium avium |
complementing thymidylate synthase | - |
Mycobacterium leprae |
complementing thymidylate synthase | - |
Mycobacterium tuberculosis |
complementing thymidylate synthase | - |
Helicobacter pylori |
complementing thymidylate synthase | - |
Rhodococcus sp. |
complementing thymidylate synthase | - |
Clostridium perfringens |
complementing thymidylate synthase | - |
Mycobacterium tuberculosis variant bovis |
complementing thymidylate synthase | - |
Clostridium botulinum |
complementing thymidylate synthase | - |
Clostridioides difficile |
complementing thymidylate synthase | - |
Corynebacterium diphtheriae |
complementing thymidylate synthase | - |
Treponema denticola |
complementing thymidylate synthase | - |
Treponema pallidum |
complementing thymidylate synthase | - |
Rickettsia prowazekii |
complementing thymidylate synthase | - |
Borreliella burgdorferi |
complementing thymidylate synthase | - |
Campylobacter jejuni |
complementing thymidylate synthase | - |
Chlamydia pneumoniae |
complementing thymidylate synthase | - |
Chlamydia psittaci |
complementing thymidylate synthase | - |
Thermotoga maritima |
complementing thymidylate synthase | - |
Bacillus anthracis |
complementing thymidylate synthase | - |
Rickettsia conorii |
complementing thymidylate synthase | - |
Ehrlichia chaffeensis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Chlamydia trachomatis | |
FAD | - |
Mycobacterium avium | |
FAD | - |
Mycobacterium leprae | |
FAD | - |
Mycobacterium tuberculosis | |
FAD | - |
Helicobacter pylori | |
FAD | - |
Rhodococcus sp. | |
FAD | - |
Clostridium perfringens | |
FAD | - |
Mycobacterium tuberculosis variant bovis | |
FAD | - |
Clostridium botulinum | |
FAD | - |
Clostridioides difficile | |
FAD | - |
Corynebacterium diphtheriae | |
FAD | - |
Treponema denticola | |
FAD | - |
Treponema pallidum | |
FAD | - |
Rickettsia prowazekii | |
FAD | - |
Borreliella burgdorferi | |
FAD | - |
Campylobacter jejuni | |
FAD | - |
Chlamydia pneumoniae | |
FAD | - |
Chlamydia psittaci | |
FAD | - |
Bacillus anthracis | |
FAD | - |
Rickettsia conorii | |
FAD | - |
Ehrlichia chaffeensis | |
FAD | tightly bound, four molecules per tetramer | Dictyostelium discoideum | |
FAD | tightly bound, four molecules per tetramer | Thermotoga maritima | |
FAD | even though FAD is very well bound to three subunits, FAD interactions are not an absolute requirement for tetramer stabilization | Thermotoga maritima | |
FADH2 | - |
Chlamydia trachomatis | |
FADH2 | - |
Mycobacterium avium | |
FADH2 | - |
Mycobacterium leprae | |
FADH2 | - |
Mycobacterium tuberculosis | |
FADH2 | - |
Helicobacter pylori | |
FADH2 | - |
Rhodococcus sp. | |
FADH2 | - |
Clostridium perfringens | |
FADH2 | - |
Mycobacterium tuberculosis variant bovis | |
FADH2 | - |
Clostridium botulinum | |
FADH2 | - |
Clostridioides difficile | |
FADH2 | - |
Corynebacterium diphtheriae | |
FADH2 | - |
Treponema denticola | |
FADH2 | - |
Treponema pallidum | |
FADH2 | - |
Rickettsia prowazekii | |
FADH2 | - |
Borreliella burgdorferi | |
FADH2 | - |
Campylobacter jejuni | |
FADH2 | - |
Chlamydia pneumoniae | |
FADH2 | - |
Chlamydia psittaci | |
FADH2 | - |
Thermotoga maritima | |
FADH2 | - |
Bacillus anthracis | |
FADH2 | - |
Rickettsia conorii | |
FADH2 | - |
Ehrlichia chaffeensis | |
NAD(P)H | required | Thermotoga maritima |