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Literature summary for 2.1.1.148 extracted from

  • Mathews, I.I.; Deacon, A.M.; Canaves, J.M.; McMullan, D.; Lesley, S.A.; Agarwalla, S.; Kuhn, P.
    Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein (2003), Structure, 11, 677-690.
    View publication on PubMed
Search for more literature for 2.1.1.148

Activating Compound

Activating Compound Comment Organism Structure
NADH
-
 Helicobacter pylori
NADH required to reduce bound FAD Dictyostelium discoideum
NADH required to reduce bound FAD Thermotoga maritima
NADPH
-
 Helicobacter pylori
NADPH required to reduce bound FAD Dictyostelium discoideum
NADPH required to reduce bound FAD Thermotoga maritima

Application

Application Comment Organism
medicine promising medical target, thyX is present in a number of pathogenic bacteria but absent in human Chlamydia trachomatis
medicine promising medical target, thyX is present in a number of pathogenic bacteria but absent in human Mycobacterium avium
medicine promising medical target, thyX is present in a number of pathogenic bacteria but absent in human Rhodococcus sp.
medicine promising medical target, thyX is present in a number of pathogenic bacteria but absent in human Clostridium perfringens
medicine promising medical target, thyX is present in a number of pathogenic bacteria but absent in human Mycobacterium tuberculosis variant bovis
medicine promising medical target, thyX is present in a number of pathogenic bacteria but absent in human Clostridium botulinum
medicine promising medical target, thyX is present in a number of pathogenic bacteria but absent in human Clostridioides difficile
medicine promising medical target, thyX is present in a number of pathogenic bacteria but absent in human Corynebacterium diphtheriae
medicine promising medical target, thyX is present in a number of pathogenic bacteria but absent in human Treponema denticola
medicine promising medical target, thyX is present in a number of pathogenic bacteria but absent in human Treponema pallidum
medicine promising medical target, thyX is present in a number of pathogenic bacteria but absent in human Rickettsia prowazekii
medicine promising medical target, thyX is present in a number of pathogenic bacteria but absent in human Borreliella burgdorferi
medicine promising medical target, thyX is present in a number of pathogenic bacteria but absent in human Campylobacter jejuni
medicine promising medical target, thyX is present in a number of pathogenic bacteria but absent in human Chlamydia pneumoniae
medicine promising medical target, thyX is present in a number of pathogenic bacteria but absent in human Chlamydia psittaci
medicine promising medical target, thyX is present in a number of pathogenic bacteria but absent in human Helicobacter pylori
medicine promising medical target, thyX is present in a number of pathogenic bacteria but absent in human Bacillus anthracis
medicine promising medical target, thyX is present in a number of pathogenic bacteria but absent in human Rickettsia conorii
medicine promising medical target, thyX is present in a number of pathogenic bacteria but absent in human Ehrlichia chaffeensis
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 Chlamydia trachomatis
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 Mycobacterium avium
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 Mycobacterium leprae
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 Mycobacterium tuberculosis
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 Helicobacter pylori
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 Rhodococcus sp.
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 Clostridium perfringens
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 Mycobacterium tuberculosis variant bovis
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 Treponema denticola
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 Treponema pallidum
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 Rickettsia prowazekii
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 Borreliella burgdorferi
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 Campylobacter jejuni
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 Chlamydia pneumoniae
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 Chlamydia psittaci
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 Bacillus anthracis
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 Rickettsia conorii
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low cross-reactivity against mammalian thyA enzymes, EC 2.1.1.45 Ehrlichia chaffeensis
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low crossreactivity against mammalian thyA enzymes, EC 2.1.1.45 Clostridium botulinum
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low crossreactivity against mammalian thyA enzymes, EC 2.1.1.45 Clostridioides difficile
medicine specific and selective inhibitors for thy1 can provide highly effective tools for therapeutic intervention with low crossreactivity against mammalian thyA enzymes, EC 2.1.1.45 Corynebacterium diphtheriae

Cloned(Commentary)

Cloned (Comment) Organism
-
 Thermotoga maritima

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Thermotoga maritima

Inhibitors

Inhibitors Comment Organism Structure
FAD
-
 Thermotoga maritima
HEPES
-
 Thermotoga maritima

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP + FADH2 Chlamydia trachomatis
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Dictyostelium discoideum
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Mycobacterium avium
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Mycobacterium leprae
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Mycobacterium tuberculosis
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Rhodococcus sp.
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Clostridium perfringens
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Mycobacterium tuberculosis variant bovis
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Clostridium botulinum
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Clostridioides difficile
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Corynebacterium diphtheriae
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Treponema denticola
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Treponema pallidum
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Rickettsia prowazekii
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Borreliella burgdorferi
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Campylobacter jejuni
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Chlamydia pneumoniae
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Chlamydia psittaci
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Helicobacter pylori
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Thermotoga maritima
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Bacillus anthracis
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Rickettsia conorii
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Ehrlichia chaffeensis
-
 dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2 Thermotoga maritima DSM 3109
-
 dTMP + tetrahydrofolate + FAD
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus anthracis
-
-
-
Borreliella burgdorferi
-
-
-
Campylobacter jejuni
-
-
-
Chlamydia pneumoniae
-
-
-
Chlamydia psittaci
-
-
-
Chlamydia trachomatis
-
-
-
Clostridioides difficile
-
-
-
Clostridium botulinum
-
-
-
Clostridium perfringens
-
-
-
Corynebacterium diphtheriae
-
-
-
Dictyostelium discoideum
-
-
-
Ehrlichia chaffeensis
-
-
-
Helicobacter pylori
-
-
-
Helicobacter pylori Q9ZJ93
-
-
Mycobacterium avium
-
-
-
Mycobacterium leprae
-
-
-
Mycobacterium leprae
-
 simultaneous occurrence of thyA and thyX
-
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis
-
 simultaneous occurrence of thyA and thyX
-
Mycobacterium tuberculosis variant bovis
-
-
-
Rhodococcus sp.
-
-
-
Rickettsia conorii
-
-
-
Rickettsia prowazekii
-
-
-
Thermotoga maritima Q9WYT0
-
-
Thermotoga maritima Q9WYT0 TM0449
-
Thermotoga maritima DSM 3109 Q9WYT0 TM0449
-
Treponema denticola
-
-
-
Treponema pallidum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Thermotoga maritima

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Chlamydia trachomatis dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Dictyostelium discoideum dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Mycobacterium avium dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Mycobacterium leprae dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Mycobacterium tuberculosis dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Helicobacter pylori dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Rhodococcus sp. dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Clostridium perfringens dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Mycobacterium tuberculosis variant bovis dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Clostridium botulinum dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Clostridioides difficile dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Corynebacterium diphtheriae dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Treponema denticola dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Treponema pallidum dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Rickettsia prowazekii dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Borreliella burgdorferi dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Campylobacter jejuni dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Chlamydia pneumoniae dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Chlamydia psittaci dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Thermotoga maritima dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Bacillus anthracis dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Rickettsia conorii dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Ehrlichia chaffeensis dTMP + tetrahydrofolate + FAD
-
 ?
5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Thermotoga maritima DSM 3109 dTMP + tetrahydrofolate + FAD
-
 ?

Subunits

Subunits Comment Organism
tetramer
-
 Helicobacter pylori
tetramer data from crystal structure Thermotoga maritima

Synonyms

Synonyms Comment Organism
complementing thymidylate synthase
-
 Chlamydia trachomatis
complementing thymidylate synthase
-
 Mycobacterium avium
complementing thymidylate synthase
-
 Mycobacterium leprae
complementing thymidylate synthase
-
 Mycobacterium tuberculosis
complementing thymidylate synthase
-
 Helicobacter pylori
complementing thymidylate synthase
-
 Rhodococcus sp.
complementing thymidylate synthase
-
 Clostridium perfringens
complementing thymidylate synthase
-
 Mycobacterium tuberculosis variant bovis
complementing thymidylate synthase
-
 Clostridium botulinum
complementing thymidylate synthase
-
 Clostridioides difficile
complementing thymidylate synthase
-
 Corynebacterium diphtheriae
complementing thymidylate synthase
-
 Treponema denticola
complementing thymidylate synthase
-
 Treponema pallidum
complementing thymidylate synthase
-
 Rickettsia prowazekii
complementing thymidylate synthase
-
 Borreliella burgdorferi
complementing thymidylate synthase
-
 Campylobacter jejuni
complementing thymidylate synthase
-
 Chlamydia pneumoniae
complementing thymidylate synthase
-
 Chlamydia psittaci
complementing thymidylate synthase
-
 Thermotoga maritima
complementing thymidylate synthase
-
 Bacillus anthracis
complementing thymidylate synthase
-
 Rickettsia conorii
complementing thymidylate synthase
-
 Ehrlichia chaffeensis

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Chlamydia trachomatis
FAD
-
 Mycobacterium avium
FAD
-
 Mycobacterium leprae
FAD
-
 Mycobacterium tuberculosis
FAD
-
 Helicobacter pylori
FAD
-
 Rhodococcus sp.
FAD
-
 Clostridium perfringens
FAD
-
 Mycobacterium tuberculosis variant bovis
FAD
-
 Clostridium botulinum
FAD
-
 Clostridioides difficile
FAD
-
 Corynebacterium diphtheriae
FAD
-
 Treponema denticola
FAD
-
 Treponema pallidum
FAD
-
 Rickettsia prowazekii
FAD
-
 Borreliella burgdorferi
FAD
-
 Campylobacter jejuni
FAD
-
 Chlamydia pneumoniae
FAD
-
 Chlamydia psittaci
FAD
-
 Bacillus anthracis
FAD
-
 Rickettsia conorii
FAD
-
 Ehrlichia chaffeensis
FAD tightly bound, four molecules per tetramer Dictyostelium discoideum
FAD tightly bound, four molecules per tetramer Thermotoga maritima
FAD even though FAD is very well bound to three subunits, FAD interactions are not an absolute requirement for tetramer stabilization Thermotoga maritima
FADH2
-
 Chlamydia trachomatis
FADH2
-
 Mycobacterium avium
FADH2
-
 Mycobacterium leprae
FADH2
-
 Mycobacterium tuberculosis
FADH2
-
 Helicobacter pylori
FADH2
-
 Rhodococcus sp.
FADH2
-
 Clostridium perfringens
FADH2
-
 Mycobacterium tuberculosis variant bovis
FADH2
-
 Clostridium botulinum
FADH2
-
 Clostridioides difficile
FADH2
-
 Corynebacterium diphtheriae
FADH2
-
 Treponema denticola
FADH2
-
 Treponema pallidum
FADH2
-
 Rickettsia prowazekii
FADH2
-
 Borreliella burgdorferi
FADH2
-
 Campylobacter jejuni
FADH2
-
 Chlamydia pneumoniae
FADH2
-
 Chlamydia psittaci
FADH2
-
 Thermotoga maritima
FADH2
-
 Bacillus anthracis
FADH2
-
 Rickettsia conorii
FADH2
-
 Ehrlichia chaffeensis
NAD(P)H required Thermotoga maritima