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Literature summary for 2.1.1.15 extracted from
- The enzymatic synthesis of fatty acid methyl esters by carboxyl group alkylation (1970), J. Biol. Chem., 245, 709-713.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | slight inhibition | Mycolicibacterium phlei |  |
| S-adenosylhomocysteine | - |
Mycolicibacterium phlei | |
| unsaturated fatty acids | - |
Mycolicibacterium phlei |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.025 | - |
S-adenosylmethionine | - |
Mycolicibacterium phlei | |
| 1.3 | - |
oleic acid | - |
Mycolicibacterium phlei | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + a fatty acid | Mycolicibacterium phlei | synthesis of 10-methylstearic acid | S-adenosyl-L-homocysteine + a fatty acid methyl ester | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycolicibacterium phlei | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | traces of activity with methionine, serine and S-adenosylethinonine as methyl donor | Mycolicibacterium phlei | ? | - |
? | |
| S-adenosyl-L-methionine + a fatty acid | oleic acid is the most effective fatty acid acceptor, traces of activity with phosphatidylethanolamine and phosphatidylglycerol | Mycolicibacterium phlei | S-adenosyl-L-homocysteine + a fatty acid methyl ester | - |
? | |
| S-adenosyl-L-methionine + a fatty acid | synthesis of 10-methylstearic acid | Mycolicibacterium phlei | S-adenosyl-L-homocysteine + a fatty acid methyl ester | - |
? | |
| S-adenosyl-L-methionine + oleic acid | oleic acid is the most effective fatty acid acceptor, traces of activity with phosphatidylethanolamine and phosphatidylglycerol | Mycolicibacterium phlei | S-adenosyl-L-homocysteine + oleic acid methyl ester | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
20% loss of activity within 5 min | Mycolicibacterium phlei |
| 100 | - |
90% loss of activity within 10 min | Mycolicibacterium phlei |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 9 | - |
Mycolicibacterium phlei |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 10 | - |
Mycolicibacterium phlei |
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Release 2023.1 (January 2023)
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