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Literature summary for 2.1.1.160 extracted from

  • Maluf, M.; Da Silva, C.; De Oliveira, M.; Tavares, A.; Silvarolla, M.; Guerreiro Filho, O.
    Altered expression of the caffeine synthase gene in a naturally caffeine-free mutant of Coffea arabica (2009), Genet. Mol. Biol., 32, 802-810.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information naturally occuring low-caffeine fruits contain an extra transcript of the caffeine synthase gene containing only part of exon 1 and all of exon 3. The sequence of the mutant caffeine synthase gene shows a substitution I266V in the enzyme active site that probably interferes with enzymatic activity. The absence of caffeine in these mutants probably results from a combination of transcriptional regulation and the presence of mutations Coffea arabica

Organism

Organism UniProt Comment Textmining
Coffea arabica Q8H0D3 CCS1
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Expression

Organism Comment Expression
Coffea arabica naturally occuring low-caffeine fruits have a lower expression of the theobromine synthase and caffeine synthase genes and also contain an extra transcript of the caffeine synthase gene encoding a mutant form. The absence of caffeine in these mutants probably results from a combination of transcriptional regulation and the presence of mutations additional information