Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine | Rattus norvegicus | the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline | S-adenosyl-L-homocysteine + phosphatidylcholine | - |
? | |
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine | Rattus norvegicus | the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline | S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine | - |
? | |
S-adenosyl-L-methionine + phosphatidylethanolamine | Rattus norvegicus | the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline. Loss of PEMT function may contribute to malignant transformation of hepatocytes | S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatoma cell | PEMT2 protein decreases in preneoplastic nodules and virtually disappears in hepatocellular carcinoma | Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine | - |
Rattus norvegicus | 2 S-adenosyl-L-homocysteine + phosphatidylcholine | - |
? | |
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine | the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline | Rattus norvegicus | S-adenosyl-L-homocysteine + phosphatidylcholine | - |
? | |
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine | - |
? | |
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine | the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline | Rattus norvegicus | S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine | - |
? | |
S-adenosyl-L-methionine + phosphatidylethanolamine | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine | - |
? | |
S-adenosyl-L-methionine + phosphatidylethanolamine | the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline. Loss of PEMT function may contribute to malignant transformation of hepatocytes | Rattus norvegicus | S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine | - |
? |