Cloned (Comment) | Organism |
---|---|
the PEMT gene is localized to chromosome 11 and spans 25 kb with seven exons and six introns, expression analysis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of Pemt-/- mice lacking all enzyme activity, but with no abnormal phenotype, normal hepatocyte morphology, normal plasma lipid levels, and no differences in bile composition compared to the wild-type mice, but the phenotype is altered after withdrawal of phosphatidylcholine and production of it, overview. In the liver-specific CTP:phosphocholine cytidylyltransferase alpha knock-out mice, PEMT activity is increased nearly 2fold above control levels. The double knockout mutant shows a dramatic decrease in hepatic phosphatidylcholine, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | - |
Mus musculus | 5789 | - |
mitochondrial membrane | - |
Mus musculus | 31966 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | physiological functions of phosphatidylcholine, mutational analysis, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | physiological functions of phosphatidylcholine, mutational analysis, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PEMT | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Mus musculus |