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Literature summary for 2.1.1.17 extracted from

  • Pynn, C.J.; Henderson, N.G.; Clark, H.; Koster, G.; Bernhard, W.; Postle, A.D.
    Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo (2011), J. Lipid Res., 52, 399-407.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine a multiple isotopomer distribution analysis approach is presented, based on transfer of deuterated methyl groups to S-adenosylmethionine and subsequent sequential methylations of phosphatidylethanolamine, to quantify absolute flux rates through the PEMT pathway that are applicable to studies of liver dysfunction in clinical studies Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
PEMT
-
Homo sapiens
phosphatidylethanolamine N-methyltransferase
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the PEMT pathway in human liver is selective for polyunsaturated phosphatidylcholine species, especially those containing docosahexaenoic acid Homo sapiens