Literature summary for 2.1.1.170 extracted from

Benitez-Paez, A.; Cardenas-Brito, S.; Corredor, M.; Villarroya, M.; Armengod, M.E.
Impairing methylations at ribosome RNA, a point mutation-dependent strategy for aminoglycoside resistance: The rsmG case (2014), Biomedica, 34, 41-49.

Search for more literature for 2.1.1.170

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Escherichia coli

Protein Variants

Protein Variants	Comment	Organism
G75A	the mutation directly affects the S-adenosyl-L-methionine binding site, presents an almost 4fold loss of affinity and maintains the enzyme active	Escherichia coli
N39A	inactive	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + guanine527 in 16S rRNA	Escherichia coli	-	S-adenosyl-L-homocysteine + N7-methylguanine527 in 16S rRNA	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0A6U5	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + guanine527 in 16S rRNA	-	Escherichia coli	S-adenosyl-L-homocysteine + N7-methylguanine527 in 16S rRNA	-	?

Synonyms

Synonyms	Comment	Organism
rsmG	-	Escherichia coli

General Information

General Information	Comment	Organism
malfunction	enzyme loss confers low-level streptomycin resistance and may affect ribosomal functioning	Escherichia coli

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Release 2023.1 (January 2023)