Literature summary for 2.1.1.179 extracted from

Tomic, T.I.; Moric, I.; Conn, G.L.; Vasiljevic, B.
Aminoglycoside resistance genes sgm and kgmB protect bacterial but not yeast small ribosomal subunits in vitro despite high conservation of the rRNA A-site (2008), Res. Microbiol., 159, 658-662.

Search for more literature for 2.1.1.179

Cloned(Commentary)

Cloned (Comment)	Organism
sgm is cloned into a yeast expression vector to test whether the prokaryotic methylases can modify the 18S rRNA A-site and thus confer resistance to the aminoglycoside antibiotic G-418. Sgm does not provide resistant phenotypes to yeast cells. Despite all similarities in the antibiotic binding site, methylation by Sgm does not occur in yeast, suggesting that the recognition site for these methylases could be different in 30S and 40S subunits	Micromonospora zionensis

Cloned (Comment)

Organism

sgm is cloned into a yeast expression vector to test whether the prokaryotic methylases can modify the 18S rRNA A-site and thus confer resistance to the aminoglycoside antibiotic G-418. Sgm does not provide resistant phenotypes to yeast cells. Despite all similarities in the antibiotic binding site, methylation by Sgm does not occur in yeast, suggesting that the recognition site for these methylases could be different in 30S and 40S subunits

Micromonospora zionensis

Organism

Organism	UniProt	Comment	Textmining
Micromonospora zionensis	Q7M0R2	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + guanine1405 in 16S rRNA	-	Micromonospora zionensis	S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA	-	?

Synonyms

Synonyms	Comment	Organism
sgm	-	Micromonospora zionensis

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)