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Literature summary for 2.1.1.180 extracted from

  • Wachino, J.; Shibayama, K.; Kurokawa, H.; Kimura, K.; Yamane, K.; Suzuki, S.; Shibata, N.; Ike, Y.; Arakawa, Y.
    Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides (2007), Antimicrob. Agents Chemother., 51, 4401-4409.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + adenosine1408 in 16S rRNA Escherichia coli the enzyme provides a panaminoglycoside-resistant nature through interference with the binding of aminoglycosides toward the A site of 16S rRNA through N-1 methylation at position A1408 S-adenosyl-L-homocysteine + N1-methyladenosine1408 in 16S rRNA
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?

Organism

Organism UniProt Comment Textmining
Escherichia coli A8C927
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-

Purification (Commentary)

Purification (Comment) Organism
His-tagged NpmA Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + adenine1408 in 16S rRNA NpmA is an adenine N-1 methyltransferase specific for the A1408 position at the A site of 16S rRNA Escherichia coli S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
-
?
S-adenosyl-L-methionine + adenosine1408 in 16S rRNA the enzyme provides a panaminoglycoside-resistant nature through interference with the binding of aminoglycosides toward the A site of 16S rRNA through N-1 methylation at position A1408 Escherichia coli S-adenosyl-L-homocysteine + N1-methyladenosine1408 in 16S rRNA
-
?

Synonyms

Synonyms Comment Organism
16S rRNA m1A1408 methyltransferase
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Escherichia coli
NpmA plasmid-mediated 16S rRNA methyltransferase Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35
-
assay at Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Escherichia coli

General Information

General Information Comment Organism
physiological function the introduction of a recombinant plasmid carrying npmA confers on Escherichia coli consistent resistance to both 4,6-disubstituted 2-deoxystreptamines, such as amikacin and gentamicin, and 4,5-disubstituted 2-deoxystreptamines, including neomycin and ribostamycin. The enzyme provides a panaminoglycoside-resistant nature through interference with the binding of aminoglycosides toward the A site of 16S rRNA through N1-methylation at position A1408 Escherichia coli