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Literature summary for 2.1.1.182 extracted from

  • Inoue, K.; Basu, S.; Inouye, M.
    Dissection of 16S rRNA methyltransferase (KsgA) function in Escherichia coli (2007), J. Bacteriol., 189, 8510-8518.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.182

Protein Variants

Protein Variants Comment Organism
E43A mutation located in the S-adenosylmethionine-binding motifs severely reduces methyltransferase activity, the mutation retains the ability to suppress the growth defect of the Era(E200K) strain at a low temperature Escherichia coli
E66A mutation located in the S-adenosylmethionine-binding motifs severely reduces methyltransferase activity, the mutation retains the ability to suppress the growth defect of the Era(E200K) strain at a low temperature Escherichia coli
G47A mutation located in the S-adenosylmethionine-binding motifs severely reduces methyltransferase activity, the mutation retains the ability to suppress the growth defect of the Era(E200K) strain at a low temperature Escherichia coli
R248A mutation at the C-terminal does not affect the methyltransferase activity and fails to suppress the growth defect of the Era(E200K) strain Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4 S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA
-
 Escherichia coli 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA
-
 ?

Synonyms

Synonyms Comment Organism
KsgA
-
 Escherichia coli

General Information

General Information Comment Organism
physiological function KsgA, in addition to its methyltransferase activity, has another unidentified function that plays a role in the suppression of the cold-sensitive phenotype of the Era(E200K) strain. The additional function may be involved in the acid shock response Escherichia coli