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Literature summary for 2.1.1.188 extracted from
- Structure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII (2003), EMBO J., 22, 183-192.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Streptococcus pneumoniae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptococcus pneumoniae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Streptococcus pneumoniae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + guanine748 in 23S rRNA | the enzyme methylates 23S rRNA at nucleotide G748, which is situated in a stem-loop (hairpin 35) at the macrolide binding site of the ribosome. Binding of RlmAII methyltransferase induces chemical shift changes in the RNA. The conformation of hairpin 35 that interacts with RlmAII is radically different from the structure this hairpin adopts within the 50S subunit | Streptococcus pneumoniae | S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| methyltransferase RlmAII | - |
Streptococcus pneumoniae |
| RlmAII | - |
Streptococcus pneumoniae |
| TlrB | - |
Streptococcus pneumoniae |
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Release 2023.1 (January 2023)
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