Crystallization (Comment) | Organism |
---|---|
in complex with S-adenosylhomocysteine and guanidinoacetate, and in complex with S-adenosyl-homocysteine and guanidine | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
E45D | decrease in kcat-value, increase in Km-value of S-adenosyl-L-methionine | Rattus norvegicus |
E45Q | decrease in kcat-value, increase in Km-value of S-adenosyl-L-methionine | Rattus norvegicus |
E45S | no residual activity | Rattus norvegicus |
Y221F | decrease in kcat-value | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
guanidine | - |
Rattus norvegicus | |
S-adenosylhomocysteine | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
S-adenosyl-L-methionine | wild-type | Rattus norvegicus | |
0.0042 | - |
S-adenosyl-L-methionine | mutant E45D | Rattus norvegicus | |
0.0088 | - |
S-adenosyl-L-methionine | mutant E45Q | Rattus norvegicus | |
0.013 | - |
Guanidinoacetate | mutant E45Q | Rattus norvegicus | |
0.022 | - |
Guanidinoacetate | mutant E45D | Rattus norvegicus | |
0.024 | - |
S-adenosyl-L-methionine | mutant Y221F | Rattus norvegicus | |
0.05 | - |
Guanidinoacetate | wild-type | Rattus norvegicus | |
2.3 | - |
Guanidinoacetate | mutant Y221F | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P10868 | recombinant protein | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine | mechanism | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + guanidinoacetate | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + creatine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GAMT | - |
Rattus norvegicus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1 | - |
S-adenosyl-L-methionine | mutant E45Q | Rattus norvegicus | |
2.1 | - |
S-adenosyl-L-methionine | mutant Y221F | Rattus norvegicus | |
2.4 | - |
S-adenosyl-L-methionine | mutant E45D | Rattus norvegicus | |
3.8 | - |
S-adenosyl-L-methionine | wild-type | Rattus norvegicus |