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Literature summary for 2.1.1.2 extracted from

  • Komoto, J.; Yamada, T.; Takata, Y.; Konishi, K.; Ogawa, H.; Gomi, T.; Fujioka, M.; Takusagawa, F.
    Catalytic mechanism of guanidinoacetate methyltransferase: crystal structures of guanidinoacetate methyltransferase ternary complexes (2004), Biochemistry, 43, 14385-14394.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with S-adenosylhomocysteine and guanidinoacetate, and in complex with S-adenosyl-homocysteine and guanidine Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
E45D decrease in kcat-value, increase in Km-value of S-adenosyl-L-methionine Rattus norvegicus
E45Q decrease in kcat-value, increase in Km-value of S-adenosyl-L-methionine Rattus norvegicus
E45S no residual activity Rattus norvegicus
Y221F decrease in kcat-value Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
guanidine
-
Rattus norvegicus
S-adenosylhomocysteine
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.002
-
S-adenosyl-L-methionine wild-type Rattus norvegicus
0.0042
-
S-adenosyl-L-methionine mutant E45D Rattus norvegicus
0.0088
-
S-adenosyl-L-methionine mutant E45Q Rattus norvegicus
0.013
-
Guanidinoacetate mutant E45Q Rattus norvegicus
0.022
-
Guanidinoacetate mutant E45D Rattus norvegicus
0.024
-
S-adenosyl-L-methionine mutant Y221F Rattus norvegicus
0.05
-
Guanidinoacetate wild-type Rattus norvegicus
2.3
-
Guanidinoacetate mutant Y221F Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P10868 recombinant protein
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine mechanism Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + guanidinoacetate
-
Rattus norvegicus S-adenosyl-L-homocysteine + creatine
-
?

Synonyms

Synonyms Comment Organism
GAMT
-
Rattus norvegicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1
-
S-adenosyl-L-methionine mutant E45Q Rattus norvegicus
2.1
-
S-adenosyl-L-methionine mutant Y221F Rattus norvegicus
2.4
-
S-adenosyl-L-methionine mutant E45D Rattus norvegicus
3.8
-
S-adenosyl-L-methionine wild-type Rattus norvegicus