Cloned (Comment) | Organism |
---|---|
expressed in Saos2, U2OS, and A-549 cells | Mus musculus |
expressed in Saos2, U2OS, and A-549 cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HCT-116 cell | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
pancreas | - |
Mus musculus | - |
pancreas | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + guanidinoacetate | - |
Mus musculus | S-adenosyl-L-homocysteine + creatine | - |
? | |
S-adenosyl-L-methionine + guanidinoacetate | - |
Homo sapiens | S-adenosyl-L-homocysteine + creatine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GAMT | - |
Mus musculus |
GAMT | - |
Homo sapiens |
guanidinoacetate methyltransferase | - |
Mus musculus |
guanidinoacetate methyltransferase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | GAMT induction in response to DNA damage is dependent upon p53, GAMT also shows p53-dependent induction in response to exogenously expressed p53 and genotoxic stress, metabolic stress induces GAMT expression to regulate creatine levels in a p53-dependent manner | up |
Homo sapiens | GAMT induction in response to DNA damage is dependent upon p53, GAMT also shows p53-dependent induction in response to exogenously expressed p53 and genotoxic stress, metabolic stress induces GAMT expression to regulate creatine levels in a p53-dependent manner | up |
General Information | Comment | Organism |
---|---|---|
physiological function | GAMT is not only involved in p53-dependent apoptosis in response to genotoxic stress but is important for apoptosis induced by glucose deprivation | Mus musculus |
physiological function | GAMT is not only involved in p53-dependent apoptosis in response to genotoxic stress but is important for apoptosis induced by glucose deprivation | Homo sapiens |