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Literature summary for 2.1.1.20 extracted from

  • Martinez-Chantar, M.L.; Vazquez-Chantada, M.; Ariz, U.; Martinez, N.; Varela, M.; Luka, Z.; Capdevila, A.; Rodriguez, J.; Aransay, A.M.; Matthiesen, R.; Yang, H.; Calvisi, D.F.; Esteller, M.; Fraga, M.; Lu, S.C.; Wagner, C.; Mato, J.M.
    Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice (2008), Hepatology, 47, 1191-1199.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information construction of GNMT knockout mice, knockout mice have elevated serum aminotransferase, methionine, and S-adenosyl-L-methionine levels and develop liver steatosis, fibrosis, and hepatocellular carcinoma, loss of GNMT induces aberrant methylation of DNA and histones, resulting in epigenetic modulation of critical carcinogenic pathways, several Ras and JAK/STAT inhibitors are reduced in liver tumors of enzyme knockout mice Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus major folate binding protein ?
-
 ?
S-adenosyl-L-methionine + glycine Mus musculus key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine S-adenosyl-L-homocysteine + N-methylglycine N-methylglycine = sarcosine ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male, construction of GNMT knockout mice
-

Source Tissue

Source Tissue Comment Organism Textmining
liver normal liver, not present in hepatocellular carcinoma Mus musculus
-
pancreas
-
 Mus musculus
-
prostate
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information major folate binding protein Mus musculus ?
-
 ?
S-adenosyl-L-methionine + glycine key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine Mus musculus S-adenosyl-L-homocysteine + N-methylglycine N-methylglycine = sarcosine ?

Synonyms

Synonyms Comment Organism
GNMT
-
 Mus musculus