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Literature summary for 2.1.1.203 extracted from

  • Hussain, S.; Tuorto, F.; Menon, S.; Blanco, S.; Cox, C.; Flores, J.V.; Watt, S.; Kudo, N.R.; Lyko, F.; Frye, M.
    The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation (2013), Mol. Cell. Biol., 33, 1561-1570.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.203

Localization

Localization Comment Organism GeneOntology No. Textmining
chromatoid body
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 Mus musculus 33391
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus NSun2 catalyzes the formation of cytosine-5 methylation in several tRNAs in vivo in tissues, including skin, liver, and testis ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
germ cell
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 Mus musculus
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liver
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 Mus musculus
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skin
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 Mus musculus
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testis
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information NSun2 catalyzes the formation of cytosine-5 methylation in several tRNAs in vivo in tissues, including skin, liver, and testis Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
cytosine-5 RNA methyltransferase
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 Mus musculus
NSUN2
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 Mus musculus

General Information

General Information Comment Organism
malfunction in the absence of NSun2, tRNAs lack specific cytosine-5 methylation modifications, which can cause reduced protein translation rates. In NSun2-depleted testes, genes encoding Ddx4, Miwi, and Tudor domain-containing (Tdr) proteins are repressed, indicating that RNA-processing and posttranscriptional pathways are impaired. Proteins of the RNA-processing machinery are reduced in NSun2-/- testes. Loss of NSun2 specifically blocks meiotic progression of germ cells into the pachytene stage, as spermatogonial and Sertoli cells are unaffected in knockout mice. Lack of NSun2 causes a block of progression of the first prophase of male meiosis at the zygotene-pachytene stage before the chromatoid bodies first appear in the cytoplasm at the late pachytene stage. Phenotype, detailed overview Mus musculus
physiological function NSun2 catalyzes the formation of cytosine-5 methylation in several tRNAs in vivo in tissues, including skin, liver, and testis. Functionally, the cytosine-5 methylation posttranscriptional modification influences translation rates, as well as correct RNA folding and stability. The mouse enzyme NSun2 is a component of the chromatoid body, NSun2 is essential for germ cell differentiation in the mouse testis. Cytosine-5 tRNA methyltransferases are dispensable for the spermatogonium and early spermatocytes Mus musculus