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Literature summary for 2.1.1.212 extracted from

  • Akashi, T.; VanEtten, H.D.; Sawada, Y.; Wasmann, C.C.; Uchiyama, H.; Ayabe, S.
    Catalytic specificity of pea O-methyltransferases suggests gene duplication for (+)-pisatin biosynthesis (2006), Phytochemistry, 67, 2525-2530.
    View publication on PubMed
Search for more literature for 2.1.1.212

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Pisum sativum
expression in Escherichia coli Glycyrrhiza echinata

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
 2,7,4'-trihydroxyisoflavanone pH 7.5, 30°C Pisum sativum
0.003
-
 2,7,4'-trihydroxyisoflavanone pH 7.5, 30°C Glycyrrhiza echinata

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone Glycyrrhiza echinata
-
 S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
 ?
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone Pisum sativum in pea, HMM1 is the equivalent of the HI4'OMT found in other legumes and is involved in formononetin biosynthesis S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
 ?

Organism

Organism UniProt Comment Textmining
Glycyrrhiza echinata Q84KK6
-
-
Pisum sativum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone
-
 Glycyrrhiza echinata S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
 ?
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone in pea, HMM1 is the equivalent of the HI4'OMT found in other legumes and is involved in formononetin biosynthesis Pisum sativum S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
 ?
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone HI4'OMT shows efficiencies (relative Vmax/Km) for the 4'-O-methylation of 2,7,4'-trihydroxyisoflavanone 20 times higher than for the 3-O-methylation of (+)-6a-hydroxymaackiain, respectively Glycyrrhiza echinata S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
 ?
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone HMM1 shows efficiencies (relative Vmax/Km) for the 4'-O-methylation of 2,7,4'-trihydroxyisoflavanone 4 times higher than for the 3-O-methylation of (+)-6a-hydroxymaackiain Pisum sativum S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
 ?

Synonyms

Synonyms Comment Organism
HI4'OMT
-
 Glycyrrhiza echinata
HMM1
-
 Pisum sativum
S-adenosyl-L-methionine: 2-hydroxyisoflavanone 4'-O-methyltransferase
-
 Pisum sativum
S-adenosyl-L-methionine: 2-hydroxyisoflavanone 4'-O-methyltransferase
-
 Glycyrrhiza echinata