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Literature summary for 2.1.1.220 extracted from

  • Anderson, J.; Phan, L.; Cuesta, R.; Carlson, B.A.; Pak, M.; Asano, K.; Björk, G.R.; Tamame, M.; Hinnebusch, A.G.
    The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA (1998), Genes Dev., 12, 3650-3662.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
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 Saccharomyces cerevisiae 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + adenine58 in initiator tRNAMet Saccharomyces cerevisiae the Gcd10p–Gcd14p complex is required specifically at the initiation step of translation because of a strong requirement for 1-methyladenosine at position 58 (m1A58) in the processing and accumulation of initiator tRNAMet S-adenosyl-L-homocysteine + N1-methyladenine58 in initiator tRNAMet
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 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P46959 and P41814 P46959: subunit Gcd14p (catalytic subunit), P41814: subunit Gcd10p (non-catalytic subunit)
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + adenine58 in initiator tRNAMet
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 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + N1-methyladenine58 in initiator tRNAMet
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 ?
S-adenosyl-L-methionine + adenine58 in initiator tRNAMet the Gcd10p–Gcd14p complex is required specifically at the initiation step of translation because of a strong requirement for 1-methyladenosine at position 58 (m1A58) in the processing and accumulation of initiator tRNAMet Saccharomyces cerevisiae S-adenosyl-L-homocysteine + N1-methyladenine58 in initiator tRNAMet
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 ?

Synonyms

Synonyms Comment Organism
Gcd10p-Gcd14p
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 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function the Gcd10p–Gcd14p complex is required specifically at the initiation step of translation because of a strong requirement for 1-methyladenosine at position 58 (m1A58) in the processing and accumulation of initiator tRNAMet Saccharomyces cerevisiae