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Literature summary for 2.1.1.220 extracted from

  • Ozanick, S.; Krecic, A.; Andersland, J.; Anderson, J.T.
    The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans (2005), RNA, 11, 1281-1290.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
coexpression of catalytic subunit Trm61p and non-catalytic subunit Trm6p in Saccharomyces cerevisiae Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96FX7 and Q9UJA5 Q96FX7: subunit Trm61p (catalytic subunit), Q9UJA5: subunit Trm6p (non-catalytic subunit)
-

Purification (Commentary)

Purification (Comment) Organism
coexpression of catalytic subunit Trm61p and non-catalytic subunit Trm6p in Saccharomyces cerevisiae, purification of the hTrm6p/hTrm61p complexes Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + adenine58 in human tRNA3Lys
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Homo sapiens S-adenosyl-L-homocysteine + N1-methyladenine58 in human tRNA3Lys
-
?
S-adenosyl-L-methionine + adenine58 in yeast initiator tRNAMet no methylation of the A58U mutant of yeast initiator tRNA(Met) Homo sapiens S-adenosyl-L-homocysteine + N1-methyladenine58 in yeast initiator tRNAMet
-
?

Synonyms

Synonyms Comment Organism
TRm61p catalytic subuni Homo sapiens
TRm6p non-catalytic subunit Homo sapiens
tRNA m1A58 methyltransferase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
assay at Homo sapiens

General Information

General Information Comment Organism
physiological function methylation of A58 is critical for maintaining the stability of initiator tRNAMet in yeast Homo sapiens