Literature summary for 2.1.1.229 extracted from

Shimada, K.; Nakamura, M.; Anai, S.; de Velasco, M.; Tanaka, M.; Tsujikawa, K.; Ouji, Y.; Konishi, N.
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression (2009), Cancer Res., 69, 3157-3164.

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Application

Application	Comment	Organism
medicine	transurethral injection of ALKBH8 small interfering RNA (siRNA) offers promise as a new therapeutic strategy for bladder cancer	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96BT7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
urothelial carcinoma cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
ALKBH8	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	silencing of ALKBH8 through small interfering RNA transfection reduced reactive oxygen species (ROS) production via down-regulation of NAD(P)H oxidase-1 (NOX-1) and induced apoptosis through subsequent activation of c-jun NH2-terminal kinase (JNK) and p38. Silencing of ALKBH8 significantly suppresses invasion, angiogenesis, and growth of bladder cancers in vivo	Homo sapiens
physiological function	ALKBH8 is an upstream target of NOX-1 and is involved in intracellular ROS generation. ALKBH8/NOX-1 signals function mainly in the acquisition of the aggressive human urothelial carcinoma phenotype	Homo sapiens

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Release 2023.1 (January 2023)