Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | stimulation of Gi-coupled adenosine type 1 receptors with N6-cyclopentyladenosine, and of other Gi-coupled receptors such as muscarinic M2 receptors (stimulated with carbachol) and angiotensin II AT2 receptors (stimulated with CGP42112) in adult rat ventricular myocytes, specifically induces methyltransferase LCMT-1 for PP2AC carboxylmethylation at Leu309 in a concentration-dependent manner. PI3K activity is upregulated in response to adenosine type 1 receptor stimulation | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | predominantly | Rattus norvegicus | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine309 | Rattus norvegicus | - |
S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine309 methyl ester | - |
? | |
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine309 | Rattus norvegicus Wistar | - |
S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine309 methyl ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q6P4Z6 | - |
- |
Rattus norvegicus Wistar | Q6P4Z6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiomyocyte | ventricular | Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine309 | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine309 methyl ester | - |
? | |
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine309 | - |
Rattus norvegicus Wistar | S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine309 methyl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LCMT-1 | - |
Rattus norvegicus |
leucine carboxylmethyltransferase-1 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme regulates the activity and subcellular localisation of type 2A protein phosphatase, PP2A, by reversible carboxylmethylation of its C-terminal leucine 309 residue. Stimulation of adenosine type 1 receptors induces PP2AC carboxylmethylation via PI3K and alters subcellular distribution in adult rat ventricular myocytes | Rattus norvegicus |