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Literature summary for 2.1.1.234 extracted from
- Three-dimensional structure of DesVI from Streptomyces venezuelae: a sugar N,N-dimethyltransferase required for dTDP-desosamine biosynthesis (2008), Biochemistry, 47, 3982-3988.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Streptomyces venezuelae |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| hanging drop method of vapor diffusion method, X-ray crystal structure determined to 2.0 A resolution of DesVI complexed with S-adenosylmethionine and the substrate analogue UDP-benzene | Streptomyces venezuelae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 S-adenosyl-L-methionine + TDP-3-amino-4,6-dideoxy-alpha-D-glucopyranose | Streptomyces venezuelae | the enzyme is involved in the biosynthesis of desosamine, an unusual sugar found on the macrolide antibiotic erythromycin, and it has been shown to play a critical role in the biological activity of the drug | 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces venezuelae | Q9ZGH6 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Streptomyces venezuelae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 S-adenosyl-L-methionine + TDP-3-amino-4,6-dideoxy-alpha-D-glucopyranose | - |
Streptomyces venezuelae | 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose | - |
? | |
| 2 S-adenosyl-L-methionine + TDP-3-amino-4,6-dideoxy-alpha-D-glucopyranose | the enzyme is involved in the biosynthesis of desosamine, an unusual sugar found on the macrolide antibiotic erythromycin, and it has been shown to play a critical role in the biological activity of the drug | Streptomyces venezuelae | 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | each subunit of the DesVI dimer contains a seven-stranded mixed beta-sheet flanked on either side by alpha-helices | Streptomyces venezuelae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DesVI | - |
Streptomyces venezuelae |
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Release 2023.1 (January 2023)
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